Changes in QuantiFERON®-TB Gold In-Tube results during treatment for tuberculous infection
| Autor: | P R Z Antas, S T de Abreu, M T C T Belo, Dick Menzies, Mayara Lisboa Bastos, Eleny Guimarães Teixeira, Anete Trajman |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Time Factors QUANTIFERON-TB GOLD Antitubercular Agents Tuberculin Medication Adherence law.invention Young Adult Randomized controlled trial Latent Tuberculosis law Internal medicine Isoniazid Humans Medicine Young adult Tuberculin Test business.industry Significant difference Skin test Middle Aged bacterial infections and mycoses Treatment Outcome Infectious Diseases Female Rifampin business Brazil Interferon-gamma Release Tests Rifampicin medicine.drug |
| Zdroj: | The International Journal of Tuberculosis and Lung Disease. 17:909-916 |
| ISSN: | 1027-3719 |
| Popis: | Setting Randomised trial comparing 9 months of isoniazid with 4 months of rifampicin for the treatment of high-risk tuberculin skin test positive subjects in Rio de Janeiro, Brazil. Objectives To compare QuantiFERON®-TB Gold In-Tube (QFT-GIT) responses before and 1, 4 and 9 months after starting treatment for latent tuberculous infection (LTBI) according to adherence to one of the two regimens. Design Participants in the trial were invited to undergo serial QFT-GIT. Within-subject differences at different time points were analysed as quantitative responses and categorised as positive or negative using different cut-off points. Results Of 215 participants, 118 completed treatment, of whom 58 underwent all three tests; and 97 did not complete treatment, of whom 10 underwent all tests. After 1 month of treatment, there was no significant difference in QFT-GIT response between the groups. After 4 and 9 months, reversions were more frequent in non-adherent subjects. Marked within-subject fluctuations were observed. No cut-off point could be established at which QFT-GIT responses were consistently positive or associated with adherence or type of treatment. Conclusion Frequent within-subject variability in QFT-GIT responses, not associated with LTBI treatment, makes it difficult for clinicians to interpret QFT-GIT conversions and reversions. |
| Databáze: | OpenAIRE |
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