Development and validation of an LC-ESI-QTOF-MS method to measure cefepime in the plasma and peritoneal fluid of rats using microdialysis: Application in a pilot pharmacokinetic study

Autor:	Michele Vaz dos Anjos, Eduarda Possa, Gisele da Silva Fonseca, Larissa Bergoza, Paulo Roberto dos Santos, Sidnei Moura e Silva, Leandro Tasso
Rok vydání:	2022
Předmět:	Pharmacology Acetonitriles Microdialysis Clinical Biochemistry Reproducibility of Results Water General Medicine Biochemistry Analytical Chemistry Rats Tandem Mass Spectrometry Gallic Acid Metronidazole Drug Discovery Animals Ascitic Fluid Rats Wistar Cefepime Molecular Biology
Zdroj:	Biomedical chromatography : BMCREFERENCES. 36(11)
ISSN:	1099-0801
Popis:	Cefepime (CEF) is a cephalosporin and can be administered in secondary peritonitis together with metronidazole to treat sepsis. This study aimed to develop and validate an LC-ESI-QTOF-MS method for the quantification of cefepime in the plasma and peritoneal microdialysate of healthy Wistar rats. Chromatographic separation was performed using a CLC-ODS C
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177e71696efbf95c5a46eaa5dca8d954 https://pubmed.ncbi.nlm.nih.gov/35904365 Zobrazit plný text záznamu Plný text