Is structural hydroxyapatite tricalcium-phosphate graft or tricortical iliac crest autograft better for calcaneal lengthening osteotomy in childhood? interim results from a randomised, controlled non-inferiority study
| Autor: | Ole Rahbek, Martin Gottliebsen, Line Kjeldgaard Pedersen, Maiken Stilling, Bjarne Møller-Madsen, Polina Martinkevich, Kjeld Søballe |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Adolescent medicine.medical_treatment Osteotomy Radiostereometric Analysis Iliac crest Bone Lengthening law.invention Ilium 03 medical and health sciences 0302 clinical medicine Non inferiority Randomized controlled trial law medicine Humans Orthopedics and Sports Medicine 030212 general & internal medicine Child 030222 orthopedics Pain Postoperative Bone Transplantation business.industry Flatfoot Surgery Calcaneus medicine.anatomical_structure Treatment Outcome Child Preschool Bone Substitutes Female Hydroxyapatites business Pes planovalgus |
| Zdroj: | Europe PubMed Central Martinkevich, P, Rahbek, O, Stilling, M, Pedersen, L K, Gottliebsen, M, Søballe, K & Møller-Madsen, B 2016, ' Is structural hydroxyapatite tricalcium-phosphate graft or tricortical iliac crest autograft better for calcaneal lengthening osteotomy in childhood? interim results from a randomised, controlled non-inferiority study ', Journal of Bone and Joint Surgery: British Volume, vol. 98-B, no. 11, pp. 1554-1562 . https://doi.org/10.1302/0301-620X.98B11.BJJ-2016-0095.R1 |
| ISSN: | 2049-4408 |
| Popis: | Aims To compare the structural durability of hydroxyapatite-tricalcium phosphate (HATCP) to autologous iliac crest bone graft in calcaneal lengthening osteotomy (CLO) for pes planovalgus in childhood. Patients and Methods We present the interim results of ten patients (HATCP, n = 6 and autograft, n = 5) with a mean age of 11.5 years (8.2 to 14.2) from a randomised controlled non-inferiority trial with six months follow-up. The primary outcome was the stability of the osteotomy as measured by radiostereometric analysis. A non-inferiority margin of ≤ 2 mm osteotomy compression was set. Results At six months the data showed that the osteotomy had been compressed by a mean 1.97 mm (99.8% confidence interval -1.65 to 5.60) more in the HATCP group than in the autograft group. Migration of the CLO grafted with HATCP stabilised at six months rather than at six weeks with autograft. Conclusion This is the first randomised trial to compare the efficacy of HATCP graft with autograft in terms of stability of CLO in children. Because of problems with the HATCP the trial was stopped. We do not recommend HATCP graft in its current structure for use in unfixed CLOs. Cite this article: Bone Joint J 2016;98-B:1554–62. |
| Databáze: | OpenAIRE |
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