Ultrasonography of the diaphragm in amyotrophic lateral sclerosis: clinical significance in assessment of respiratory functions
| Autor: | Mayumi Sakata, Hideto Miwa, Yasuhiro Hiwatani |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Diaphragm Sensitivity and Specificity Pulmonary function testing medicine Humans Respiratory function Clinical significance Respiratory system Amyotrophic lateral sclerosis Aged Ultrasonography business.industry Amyotrophic Lateral Sclerosis Reproducibility of Results medicine.disease Surgery Hypoventilation Diaphragm (structural system) Respiratory Function Tests Apposition Neurology Female Neurology (clinical) medicine.symptom business Nuclear medicine Respiratory Insufficiency |
| Zdroj: | Amyotrophic lateral sclerosisfrontotemporal degeneration. 14(2) |
| ISSN: | 2167-9223 |
| Popis: | Our objective was to evaluate diaphragm thicknesses during respiration by ultrasonography, and compare with conventional measurements of respiratory functions in patients with amyotrophic lateral sclerosis (ALS). Thirty-six consecutive ALS patients and 19 age-matched healthy volunteers participated. Ultrasonography of the diaphragm in the zone of apposition was performed. Maximal diaphragm thickness during the maximal inspiratory effort (DTmax) and minimum diaphragm thickness at the end expiratory position (DTmin) were measured using ultrasonography. The thickening ratio (TR), defined as the ratio of DTmin to DTmax, was calculated. All patients underwent conventional pulmonary function testing. Arterial blood gas analysis was also performed. The diaphragm was clearly identifiable by ultrasonography. DTmax, DTmin and the TR were all significantly decreased in ALS patients with %VC (vital capacity)80, compared with those in either ALS patients with %VC ≥ 80 or healthy controls. DTmax, DTmin and the TR were all significantly correlated with %VC. In addition, significant inverse correlations were found between all three parameters and pCO(2). The inter-observer reliability of measurements of diaphragm thickness was high. In conclusion, sonography of the diaphragm can provide additional or complementary information for assessing respiratory functions in patients with ALS. |
| Databáze: | OpenAIRE |
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