Ten year follow-up of healthy children who received one or two injections of varicella vaccine
| Autor: | Penelope H. Dennehy, Keith S. Reisinger, Henry R. Shinefield, Barbara Watson, Steve Black, Jonathan Hartzel, Ivan H. Chan, Barbara J. Kuter, Lee Lian Kim, Holly Matthews, Lisa Lupinacci |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Microbiology (medical) Herpesvirus 3 Human medicine.medical_specialty Pediatrics Time Factors Varicella vaccine viruses Enzyme-Linked Immunosorbent Assay medicine.vaccine Antibodies Viral Vaccines Attenuated Herpes Zoster Risk Assessment Serology Chickenpox Vaccine Age Distribution Chickenpox medicine Humans Sex Distribution Child Immunization Schedule Probability MMRV vaccine integumentary system business.industry Incidence Incidence (epidemiology) Vaccination Immunity Infant virus diseases Vaccine efficacy Surgery Regimen Infectious Diseases Child Preschool Pediatrics Perinatology and Child Health Female Viral disease business Follow-Up Studies |
| Zdroj: | The Pediatric Infectious Disease Journal. 23:132-137 |
| ISSN: | 0891-3668 |
| DOI: | 10.1097/01.inf.0000109287.97518.67 |
| Popis: | The rate of varicella and persistence of varicella antibody after a one dose vs. a two dose regimen of varicella virus vaccine live Oka/Merck (VARIVAX; MerckCo., Inc., West Point, PA) in approximately 2000 children were compared during a 9- to 10-year follow-up period.Children 12 months to 12 years of age with a negative history of varicella were randomized in late 1991 to early 1993 to receive either one or two injections of varicella vaccine given 3 months apart. Subjects were actively followed for varicella, any varicella-like illness or zoster and any exposures to varicella or zoster on a yearly basis for 10 years after vaccination. Persistence of varicella antibody was measured yearly for 9 years.Most cases of varicella reported in recipients of one or two injections of vaccine were mild. The risk of developing varicella42 days postvaccination during the 10-year observation period was 3.3-fold lower (P0.001) in children who received two injections than in those who received one injection (2.2% vs. 7.3%, respectively). The estimated vaccine efficacy for the 10-year observation period was 94.4% for one injection and 98.3% for two injections (P0.001). Measurable serum antibody persisted for 9 years in all subjects.Administration of either one or two injections of varicella vaccine to healthy children results in long term protection against most varicella disease. The two dose regimen was significantly more effective than a single injection. |
| Databáze: | OpenAIRE |
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