Noncoding RNAs in Calcific Aortic Valve Disease: A Review of Recent Studies
| Autor: | Ying-Zhong Wu, Wen-Juan Ni, Xiao-Min Leng, Dong-Hong Ma |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Genetic Markers
0301 basic medicine Aortic valve disease RNA Untranslated Cardiovascular research Disease Bioinformatics Heart valve disorder 03 medical and health sciences Predictive Value of Tests microRNA Animals Humans Medicine Pharmacology Regulation of gene expression business.industry Calcinosis RNA Aortic Valve Stenosis Genetic Therapy 030104 developmental biology Gene Expression Regulation Aortic Valve Cardiology and Cardiovascular Medicine business Signal Transduction |
| Zdroj: | Journal of Cardiovascular Pharmacology. 71:317-323 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/fjc.0000000000000569 |
| Popis: | Calcific aortic valve disease (CAVD) is the most common heart valve disorder in human populations. Nevertheless, there are presently no effective means for its prevention and treatment. It is therefore critical to comprehensively define key mechanisms of the disease. A major focus of cardiovascular research has been characterization of how regulation of gene expression maintains healthy physiologic status of the component tissues of the system and how derangements of gene regulation may become pathological. Recently, substantial evidence has emerged that noncoding RNAs, which are an enormous and versatile class of regulatory elements, such as microRNAs and long noncoding RNAs, have roles in onset and prognosis of CAVD. Authors of the present report have therefore here provided a summary of the current understanding of contributions made by noncoding RNAs major features of CAVD. It is anticipated that this article will serve as a valuable guide to research strategy in this field and may additionally provide both researchers and clinicians with an expanded range of CAVD-associated biomarkers. |
| Databáze: | OpenAIRE |
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