High Bromide Intake Affects the Accumulation of Iodide in the Rat Thyroid and Skin
| Autor: | Miloslav Vobecký, Arnošt Babický, Jaroslav Lener, Stanislav Pavelka |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Bromides
Male medicine.medical_specialty Adult male Endocrinology Diabetes and Metabolism Clinical Biochemistry Iodide Thyroid Gland chemistry.chemical_element 010403 inorganic & nuclear chemistry Iodine 01 natural sciences Biochemistry Iodine Radioisotopes Inorganic Chemistry 03 medical and health sciences chemistry.chemical_compound Rat Thyroid 0302 clinical medicine Bromide Internal medicine medicine Animals Rats Wistar Skin chemistry.chemical_classification Body Weight Biochemistry (medical) Thyroid Organ Size General Medicine medicine.disease Iodine deficiency Diet Rats 3. Good health 0104 chemical sciences Kinetics Endocrinology medicine.anatomical_structure chemistry 030217 neurology & neurosurgery Half-Life |
| Zdroj: | Biological Trace Element Research. 82:133-142 |
| ISSN: | 0163-4984 |
| DOI: | 10.1385/bter:82:1-3:133 |
| Popis: | The effect of a high bromide intake on the kinetics of iodide uptake and elimination in the thyroid and skin of adult male rats was studied. In rats fed a diet with sufficient iodine supply (25 microg I/d), the iodide accumulation in the skin predominated during the first hours after 131I iodide application. From this organ, radioiodide was gradually transferred into the thyroid. A high bromide intake (150 mg Br-/d) in these animals led to a marked decrease in iodide accumulation, especially by the thyroid, because of an increase in iodide elimination both from the thyroid and from the skin. In rats kept under the conditions of iodine deficiency (1 micro I/d), the iodide accumulation in the thyroid, but not in the skin, was markedly increased as a result of a thyrotropic stimulation. The effect of a high bromide intake (100 mg Br-/d) in these animals was particularly pronounced because the rates of iodide elimination were most accelerated both from their thyroid and from their skin. |
| Databáze: | OpenAIRE |
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