Hippocampal Lnx1–NMDAR multiprotein complex mediates initial social memory
| Autor: | Yuan-Bo Pan, Xian Dong Liu, Nan-Jie Xu, Xiao Na Zhu, Dong Fu Feng, Peng Hui Ai, Tian Le Xu, Michael M. Halford, Mark Henkemeyer, Suya Sun |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Scaffold protein Ubiquitin-Protein Ligases PDZ domain Hippocampal formation Biology Biochemistry Receptors N-Methyl-D-Aspartate Article 03 medical and health sciences Cellular and Molecular Neuroscience Mice 0302 clinical medicine Postsynaptic potential Memory Animals Social Behavior Molecular Biology Memory Disorders Glutamate receptor Gene targeting CA3 Region Hippocampal Social relation Psychiatry and Mental health 030104 developmental biology nervous system NMDA receptor Neuroscience 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Molecular Psychiatry |
| ISSN: | 1476-5578 1359-4184 |
| Popis: | Social interaction and communication are evolutionary conserved behaviours that are developed in mammals to establish partner cognition. Deficit in sociability has been represented in human patients and animal models of neurodevelopmental disorders, which are connected with genetic variants of synaptic glutamate receptors and associated PDZ-binding proteins. However, it remains elusive how these key proteins are specialized in the cellular level for the initial social behaviour during postnatal developmental stage. Here we identify a hippocampal CA3 specifically expressed PDZ scaffold protein Lnx1 required for initial social behaviour. Through gene targeting we find that Lnx1 deficiency led to a hippocampal subregional disorder in neuronal activity and social memory impairments for partner discrimination observed in juvenile mice which also show cognitive defects in adult stage. We further demonstrate that Lnx1 deletion causes NMDA receptor (NMDAR) hypofunction and this is attributable to decreased GluN2B expression in PSD compartment and disruption of the Lnx1–NMDAR–EphB2 complex. Specific restoration of Lnx1 or EphB2 protein in the CA3 area of Lnx1−/− mice rescues the defective synaptic function and social memory. These findings thus reveal crucial roles of postsynaptic NMDAR multiprotein complex that regulates the formation of initial social memory during the adolescent period. |
| Databáze: | OpenAIRE |
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