PK 10139 and quinidine: interactions with digoxin concentrations in rats and dogs
| Autor: | C. Jozefczak, Andre Uzan, G. Le Fur, Caroline Rougeot, M. Mestre |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Quinidine
Male medicine.medical_specialty Digoxin medicine.medical_treatment Pharmaceutical Science Antiarrhythmic agent Pharmacology Dogs Species Specificity Internal medicine polycyclic compounds medicine Animals Drug Interactions cardiovascular diseases Chemistry digestive oral and skin physiology Rats Inbred Strains Drug interaction Rats carbohydrates (lipids) Endocrinology Plasma concentration Injections Intravenous Quinolines Anti-Arrhythmia Agents medicine.drug |
| Zdroj: | The Journal of pharmacy and pharmacology. 36(5) |
| ISSN: | 0022-3573 |
| Popis: | Quinidine induced an increase in digoxin plasma concentrations in rats and dogs. PK 10139, an antiarrhythmic agent 10 times more potent than quinidine, did not change digoxin plasma concentrations in these species. The results indicate that PK 10139 could be associated with digoxin without risk of side-effects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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