Risk of hip fracture in patients on dialysis or kidney transplant: a meta-analysis of 14 cohort studies
| Autor: | Jiachang Tan, Yuping Li, Jinmin Zhao, Zhenjie Wu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Therapeutics and Clinical Risk Management medicine.medical_treatment Population 030232 urology & nephrology 030209 endocrinology & metabolism dialysis or kidney transplant Peritoneal dialysis 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics education Dialysis Original Research risk education.field_of_study Hip fracture Chemical Health and Safety business.industry Retrospective cohort study General Medicine medicine.disease meta-analysis hip fracture Relative risk Hemodialysis business Safety Research Cohort study |
| Zdroj: | Therapeutics and Clinical Risk Management |
| ISSN: | 1178-203X |
| Popis: | Jiachang Tan,1,* Yuping Li,2,* Zhenjie Wu,1,* Jinmin Zhao3 1Department of Bone and Soft Tissue Surgery, Affiliated Tumor Hospital, Guangxi Medical University, Nanning 530021, People’s Republic of China; 2The First Clinical Medical College, Guangxi Medical University, Nanning 530021, People’s Republic of China; 3Department of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital, Guangxi Medical University, Nanning 530021, People’s Republic of China *These authors contributed equally tothis work Purpose: We aimed to conduct a meta-analysis of published cohort studies to evaluate the risk of hip fracture in patients undergoing dialysis or kidney transplantation (KT).Methods: We identified relevant studies by searching PubMed, EMBASE and Google Scholar databases from their inception to December 31, 2017. Cohort studies evaluating risk of hip fractures in patients undergoing dialysis or KT were considered included. The methodological quality of the cohort studies was assessed using the modified Newcastle-Ottawa scale.Results: In our meta-analysis of 14 retrospective cohort studies, a total of more than 1.5 million patients undergoing dialysis or KT were included, of whom more than 30,000 had hip fractures. After the merger, the proportion of hip fractures was 1.92% (95% CI, 1.38%-2.46%) with significant heterogeneity (I2=99.9%, P=0.000) in all patients, and the incidence rate of hip fractures (per 1,000 person-years) was 8.95 (95% CI, 4.05–13.85) with significant heterogeneity (I2=99.9%, P=0.000). The pooled relative risks (RR) value for dialysis patients compared with the general population were 6.35 (95% CI, 4.53–8.88) for male and 5.57 (95% CI, 4.44–6.99) for female. The pooled RR value for hemodialysis (HD) patients compared with peritoneal dialysis (PD) patients was 1.39 (95% CI, 1.13–1.70) with no heterogeneity (I2=0.0%, P=0.763).Conclusion: In conclusion, the present meta-analysis reveals that about 2% of dialysis or KT patients go on to sustain a hip fracture during follow-up, with the overall hip fracture incidence rates being 8.95 per 1,000 person-years. The overall risk of hip fracture was more than 5-fold higher in dialysis patients than in the general population. Among patients on PD, HD, and KT, HD and KT patients had the highest and the lowest risk of hip fractures, respectively. Keywords: risk, hip fracture, dialysis or kidney transplant, meta-analysis |
| Databáze: | OpenAIRE |
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