RhoA Pathway and Actin Regulation of the Golgi/Centriole Complex
| Autor: | Jarek Wosik, Malgorzata Kloc, Jacek Z. Kubiak, Ahmed Uosef, Rafik M. Ghobrial |
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| Přispěvatelé: | The University of Texas M.D. Anderson Cancer Center [Houston], University of Houston, Institut de Génétique et Développement de Rennes (IGDR), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), University of Houston, UHMinistry of National Defense, MND 571/2016/DAWilliam and Ella Owens Medical Research FoundationNIH P30CA0166725508/2017/DA, Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) |
| Rok vydání: | 2019 |
| Předmět: |
RHOA
actin filament Centriole [SDV]Life Sciences [q-bio] Golgi Apparatus macromolecular substances 03 medical and health sciences symbols.namesake centriole Small GTPase Cytoskeleton Actin Centrioles 030304 developmental biology Actin nucleation 0303 health sciences biology Chemistry Golgi apparatus Actin cytoskeleton Actins Golgi complex Cell biology Actin Cytoskeleton biology.protein symbols RhoA guanine nucleotide binding protein rhoA GTP-Binding Protein actin metabolism |
| Zdroj: | Results and Problems in Cell Differentiation ISBN: 9783030231729 The Golgi Apparatus and Centriole. Results and Problems in Cell Differentiation The Golgi Apparatus and Centriole. Results and Problems in Cell Differentiation, 67, Springer Verlag, pp.81-93, 2019, 978-3-030-23173-6. ⟨10.1007/978-3-030-23173-6_5⟩ |
| DOI: | 10.1007/978-3-030-23173-6_5 |
| Popis: | International audience; In vertebrate cells, the Golgi apparatus is located in close proximity to the centriole. The architecture of the Golgi/centriole complex depends on a multitude of factors, including the actin filament cytoskeleton. In turn, both the Golgi and centriole act as the actin nucleation centers. Actin organization and polymerization also depend on the small GTPase RhoA pathway. In this chapter, we summarize the most current knowledge on how the genetic, magnetic, or pharmacologic interference with RhoA pathway and actin cytoskeleton directly or indirectly affects architecture, structure, and function of the Golgi/centriole complex. |
| Databáze: | OpenAIRE |
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