Association of Lipopolysaccharide-Binding Protein With Aging-Related Adiposity Change and Prediabetes Among African Ancestry Men
| Autor: | Allison L. Kuipers, Alan L. Patrick, Joseph M. Zmuda, Cara S. Nestlerode, Curtis Tilves, Clareann H. Bunker, Rhobert W. Evans, Iva Miljkovic |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Adult Blood Glucose Male medicine.medical_specialty Aging Endocrinology Diabetes and Metabolism Black People 030209 endocrinology & metabolism Type 2 diabetes Prediabetic State 03 medical and health sciences 0302 clinical medicine Insulin resistance Blood serum Internal medicine Internal Medicine medicine Glucose homeostasis Humans Prediabetes Obesity Prospective Studies Epidemiology/Health Services Research Adiposity Aged Advanced and Specialized Nursing Membrane Glycoproteins business.industry Odds ratio Middle Aged medicine.disease Impaired fasting glucose 030104 developmental biology Endocrinology Cross-Sectional Studies business Carrier Proteins Body mass index Biomarkers Acute-Phase Proteins |
| Zdroj: | Diabetes Care |
| ISSN: | 1935-5548 0149-5992 |
| Popis: | OBJECTIVE Cross-sectional studies suggest that lipopolysaccharide-binding protein (LBP) may be associated with obesity and metabolic disorders. However, prospective studies examining LBP are lacking. This prospective study investigated the association between LBP and metabolic abnormalities in 580 African ancestry men (mean age, 59.1 ± 10.5 years). RESEARCH DESIGN AND METHODS We measured fasting serum LBP at baseline. Changes in adiposity and glucose homeostasis as well as case subjects with new type 2 diabetes and impaired fasting glucose (IFG) were assessed at a follow-up visit ˜6 years later. Baseline LBP values were tested across quartiles for linear trend with metabolic measures. Multivariable logistic regression was used to determine the odds of new cases of IFG or diabetes per 1-SD greater baseline LBP. RESULTS LBP was significantly associated with baseline BMI, waist circumference, whole-body and trunk fat, skeletal muscle density, fasting serum insulin, and HOMA-insulin resistance (IR) (all P < 0.01). Greater baseline LBP was significantly associated with longitudinal increases in the percentage of trunk fat (P = 0.025) and HOMA-IR (P = 0.034), but only borderline so with a decrease in skeletal muscle density (P = 0.057). In men with normal glucose, baseline LBP was associated with increased odds of having IFG at follow-up after adjustment for age, baseline trunk fat, and lifestyle factors (odds ratio per 1-SD LBP: 1.51; 95% CI 1.02–2.21). This association was attenuated after additional adjustment for change in trunk fat (P = 0.067). CONCLUSIONS LBP may be a marker of prediabetes. Some of this association appears to be mediated through increased central and ectopic skeletal muscle adiposity. |
| Databáze: | OpenAIRE |
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