An Efficient Synthesis of Substituted Cytosines and Purines under Focused Microwave Irradiation

Autor:	Jing-Pei Jang, Yi-Ling Chao, Ling-Kuen Huang, Yen-Chih Cherng, Y. S. Cheng, Yie-Jia Cherng
Rok vydání:	2007
Předmět:	Purine Chemistry Organic Chemistry General Medicine Biochemistry Combinatorial chemistry chemistry.chemical_compound Nucleophile Drug Discovery Microwave irradiation Organic chemistry Purine derivative Single displacement reaction Purine metabolism Cytosine
Zdroj:	ChemInform. 38
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200737153
Popis:	A rapid nucleophilic displacement reaction of 6-chloropurine, 2-amino-6-chloropurine and 5-bromocytosine with various nucleophiles under focused microwave irradiation is described. Using this method, the desired products were obtained with the yields up to 99% in a short reaction time.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1774e9e6ef70f2e87d03fafc158e1a23 https://doi.org/10.1002/chin.200737153 Zobrazit plný text záznamu Plný text