Continuous hemofiltration model using porcine blood for comparing filter life
| Autor: | Yosuke Ushiroda, Yoshitaka Kurihara, Kozue Kobayashi, Tomoyo Ebine, Kaya Murakami, Shunichi Ueki, Naoko Maruyama, Yuta Kobayashi, Kenichi Kokubo, Hirosuke Kobayashi, Hiroshi Tsukao |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Evaluation system
Chromatography Chemistry Swine 030232 urology & nephrology Biomedical Engineering Medicine (miscellaneous) Anticoagulants 030204 cardiovascular system & hematology Nafamostat mesilate Guanidines Transmembrane pressure Continuous hemofiltration Benzamidines Biomaterials 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Animals Citrates Hemofiltration Cardiology and Cardiovascular Medicine Porcine blood Trisodium citrate |
| Zdroj: | Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs. 21(3) |
| ISSN: | 1619-0904 |
| Popis: | The purpose of the present study was to establish a continuous hemofiltration model using porcine blood to compare filter life. Continuous hemofiltration (CHF) experiments were performed using an in vitro hemofilter evaluation system utilizing porcine blood containing trisodium citrate in addition to nafamostat mesilate as anticoagulants. The lifetime of the hemofilter was evaluated using the transmembrane pressure and the pressure drop across the hemofilter at varying trisodium citrate concentrations. The porcine blood used in this experiment was considered to be in a slightly hypercoagulable state because of the continuous contact with non-biological materials and calcium inflow from substitution fluid. Blood containing 7 or 8 mM of trisodium citrate and nafamostat mesilate could be effectively used to compare the lifetimes of hemofilters utilized under the same conditions. In this CHF model using porcine blood, the plugging of the hollow fibers occurred shortly after the plugging of the membrane pores. In conclusion, a CHF model using porcine blood can be established by adjusting the concentration of trisodium citrate added to the blood. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink