Effects of antioxidant vitamins C and E on endothelial function and thrombosis/fibrinolysis system in smokers
| Autor: | Costas Tsioufis, Marina Toutouza, George Goumas, Kyriakoula Marinou, Christodoulos Stefanadis, Pavlos Toutouzas, Costas Tentolouris, Charalambos Antoniades, Dimitris Tousoulis |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Vitamin medicine.medical_specialty Endothelium medicine.medical_treatment Ascorbic Acid Antioxidants chemistry.chemical_compound Internal medicine Fibrinolysis medicine Humans Vitamin E Endothelial dysfunction Reactive hyperemia Hemostasis Vitamin C business.industry Smoking Thrombosis Hematology medicine.disease Blood Coagulation Factors Endocrinology medicine.anatomical_structure chemistry Immunology Drug Therapy Combination Female Endothelium Vascular business Plasminogen activator Blood Flow Velocity |
| Zdroj: | Europe PubMed Central |
| Popis: | SummarySmoking is associated with endothelial dysfunction and abnormalities in thrombosis/fibrinolysis system, possibly through increased oxidative stress. In this study we investigated the effect of combined antioxidant treatment with vitamins C and E on endothelial function and plasma levels of plasminogen activator inhibitor (PAI-1), von Willebrand factor (vWF), tissue plasminogen activator (tPA) and factor VII (fVII), in smokers. Forty-one healthy smokers were randomly divided into 4 groups receiving vitamin C 2g/day (group A), vitamin C 2g/day plus vitamin E 400IU/day (group B), vitamin C 2g/day plus vitamin E 800IU/day (group C) or no antioxidants (controls, group D), for 4 weeks. Forearm blood flow was measured using venous occlusion strain-gauge plethysmography. Forearm vasodilatory response to reactive hyperemia (RH%) or to sublingual nitroglycerin administration (NTG%) were considered as indexes of endothelium dependent or independent dilation respectively. After treatment, RH% was increased only in groups B (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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