Eligibility for low-dose computerized tomography screening among asbestos-exposed individuals
| Autor: | William K. Evans, Natalie R. Fitzgerald, Anthony B. Miller, William M. Flanagan |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Canada Lung Neoplasms Cost effectiveness Cost-Benefit Analysis Guidelines as Topic medicine.disease_cause Risk Assessment Asbestos asbestos exposure Age Distribution Internal medicine medicine cancer Humans Computer Simulation Risk factor Lung cancer cost-effectiveness Early Detection of Cancer Aged business.industry Low dose Smoking Public Health Environmental and Occupational Health microsimulation mathematical modeling Cancer Environmental Exposure Middle Aged Models Theoretical medicine.disease lung cancer risk factor exposure low-dose computerized tomography Relative risk Cohort Asbestosis Quality-Adjusted Life Years Public aspects of medicine RA1-1270 business Nuclear medicine Tomography X-Ray Computed ct |
| Zdroj: | Scandinavian Journal of Work, Environment & Health, Vol 41, Iss 4, Pp 407-412 (2015) |
| ISSN: | 1795-990X |
| Popis: | Objectives The study aimed to incorporate an estimate of risk for asbestos exposure in the Canadian Cancer Risk Management Lung Cancer (CRMM-LC) microsimulation model. Methods In CRMM-LC, a 3-year probability of developing lung cancer can be derived from different risk profiles. An asbestos-exposed cohort was simulated and different scenarios of low-dose computerized tomography (LDCT) screening were simulated. Results As annual LDCT screening among non-asbestos-exposed individuals is less cost-effective than biennial screening, all the scenarios modeled for an asbestos-exposed cohort were biennial. For individuals with a two-fold risk of asbestos-induced lung cancer to be eligible for biennial LDCT screening, a smoking history of ≥15 pack-years would be necessary. For non-smokers with asbestos exposure resulting in a relative risk (RR) for lung cancer, it is not cost-effective to screen those with a RR of 5, but it is cost-effective to screen those with a RR of 10 (the heavily exposed). Conclusion Asbestos-exposed individuals with an estimated two-fold or more risk of lung cancer from asbestos-exposure are eligible for LDCT screening at all ages from 55–74 years if they have a cigarette smoking history of ≥15 pack-years. Asbestos-exposed individuals who are lifelong non-smokers are eligible for LDCT screening at all ages from 55–74 years if they have accumulated a degree of asbestos exposure resulting in an estimated risk of lung cancer of ≥10. |
| Databáze: | OpenAIRE |
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