Sub-10-nm multicolored gold nanoparticles for colorimetric determination of antibiotics via formation of interlocking rings
| Autor: | Yumin Leng, Zhiwen Lu, Linfeng Ma, Kecheng Liu, Fu Yu, Zhipei Sang, Chenxi Du |
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| Rok vydání: | 2019 |
| Předmět: |
Metal Nanoparticles
Nanochemistry Food Contamination 02 engineering and technology 010402 general chemistry 01 natural sciences Analytical Chemistry Limit of Detection medicine Animals Particle Size Detection limit Chemistry Spiramycin Water 021001 nanoscience & nanotechnology Thiamphenicol Anti-Bacterial Agents 0104 chemical sciences Milk Certified reference materials Linear range Colloidal gold Colorimetry Gold 0210 nano-technology Colorimetric analysis Water Pollutants Chemical medicine.drug Nuclear chemistry |
| Zdroj: | Microchimica Acta. 186 |
| ISSN: | 1436-5073 0026-3672 |
| DOI: | 10.1007/s00604-019-3949-9 |
| Popis: | A general approach is presented for synthesis of multicolored gold nanoparticles (GNPs) by Au(I)-mediated generation of interlocking rings in proteins and antibiotics. The Au(I) ions are shuttled from proteins to antibiotics, and this causes the formation of interlocking rings. The multicolored GNPs of different sizes were synthesized in the rings by using the rapid nucleation method. To take the unique colors of GNPs, a functional array was designed for the colorimetric determination and discrimination of antibiotics, specifically of amoxicillin, chlortetracycline, erythromycin, spiramycin, neomycin, thiamphenicol, gentamycin and lincomycin. The method is based on the "three color" (RGB) principle. The color response patterns are characteristic for each antibiotic and can be quantitatively differentiated by statistical techniques. The limits of detection (LOD, at S/N = 3) for spiramycin (Sp) have been calculated to be 0.18 μM and 0.10 μM in water and milk, respectively. The good linear range (from 0.3 to 3.5 μM) has been used for the quantitative assay of Sp in a certified reference material. Graphical abstractSchematic presentation of gold nanoparticles (GNPs) synthesis via formation of interlocking rings in protein and antibiotics. The Au(I) ions mediate protein and antibiotics to be interlocking rings, which are quickly fixed via microwave reaction. The GNPs are synthesized and assembled in the rings. |
| Databáze: | OpenAIRE |
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