m6A RNA methylation regulators could contribute to the occurrence of chronic obstructive pulmonary disease
| Autor: | Min Li, Hong Zhang, Dong-Jin Lv, Xinwei Huang, Xiao Yang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adenosine RNA methylation Biology Methylation chronic obstructive pulmonary disease Pulmonary Disease Chronic Obstructive 03 medical and health sciences 0302 clinical medicine Gene expression medicine Humans KEGG Gene Genetics IGF2BP3 Messenger RNA COPD Gene Expression Profiling Weighted correlation network analysis Original Articles bioinformatics Cell Biology medicine.disease Hedgehog signaling pathway Gene Ontology m6A RNA methylation regulators 030104 developmental biology Gene Expression Regulation Case-Control Studies 030220 oncology & carcinogenesis RNA METTL3 Molecular Medicine Original Article |
| Zdroj: | Journal of Cellular and Molecular Medicine |
| ISSN: | 1582-4934 1582-1838 |
| DOI: | 10.1111/jcmm.15848 |
| Popis: | N6‐methyladenosine (m6A) RNA methylation, the most prevalent internal chemical modification of mRNA, has been reported to participate in the progression of various tumours via the dynamic regulation of m6A RNA methylation regulators. However, the role of m6A RNA methylation regulators in chronic obstructive pulmonary disease (COPD) has never been reported. This study aimed to determine the expression and potential functions of m6A RNA methylation regulators in COPD. Four gene expression data sets were acquired from Gene Expression Omnibus. Gene ontology function, Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses, weighted correlation network analysis and protein‐protein interaction network analysis were performed. The correlation analyses of m6A RNA methylation regulators and key COPD genes were also performed. We found that the mRNA expressions of IGF2BP3, FTO, METTL3 and YTHDC2, which have the significant associations with some key genes enriched in the signalling pathway and biological processes that promote the development progression of COPD, are highly correlated with the occurrence of COPD. In conclusion, six central m6A RNA methylation regulators could contribute to the occurrence of COPD. This study provides important evidence for further examination of the role of m6A RNA methylation in COPD. |
| Databáze: | OpenAIRE |
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