Phytochemicals as Potential Therapeutics for SARS-CoV-2–Induced Cardiovascular Complications: Thrombosis and Platelet Perspective
| Autor: | Abhishek R. Panigrahi, Samir K. Beura, Sunil Kumar Singh, Pooja Yadav |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Chemokine Myocarditis ACE2 Review phytochemical RM1-950 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Immune system medicine Platelet Pharmacology (medical) myocardial injury Thrombus thrombosis Pharmacology platelet biology business.industry SARS-CoV-2 medicine.disease Thrombosis 030104 developmental biology Coagulation Immunology cytokine storm biology.protein Therapeutics. Pharmacology Cytokine storm business |
| Zdroj: | Frontiers in Pharmacology, Vol 12 (2021) Frontiers in Pharmacology |
| ISSN: | 1663-9812 |
| DOI: | 10.3389/fphar.2021.658273/full |
| Popis: | After gaining entry through ACE2 aided by TMPRSS2, the SARS-CoV-2 causes serious complications of the cardiovascular system leading to myocarditis and other myocardial injuries apart from causing lung, kidney and brain dysfunctions. Here in this review, we are going to divulge the cellular and immunological mechanisms behind the cardiovascular, thrombotic and platelet impairments that are caused in COVID-19. In addition, we also propose the significance of various anti-platelet and anti-thrombotic phytochemicals in the treatment of COVID-19. The virus induces many immune-modulatory cytokines and chemokines which help in the intravascular coagulation and create a pro-thrombotic environment along with pulmonary embolism and thrombocytopenia. Different types of innate and adaptive immune cells and their granular contents regulate the pathophysiology of SARS-CoV-2 induced endothelial and platelet dysfunctions which correlate the involvement of platelets with myocardial injury and intravascular thrombi directly or indirectly. Hence, by exploiting the natural bioactive compounds from medicinal plants and inhibiting the platelet mediated thrombus formation can be beneficial for the treatment of SARS-CoV-2 infection. |
| Databáze: | OpenAIRE |
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