Neoplasia-Associated Pericarditis—Predictor of Cancer Progression?

Autor: Alina Gabriela Negru, Anca Tudor, Laura Mazilu, Sorin Săftescu, Anca Boldan, Maria Boldan, Constantin Tudor Luca, Șerban Negru, Dorel Popovici
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Diagnostics
Volume 11
Issue 1
Diagnostics, Vol 11, Iss 58, p 58 (2021)
ISSN: 2075-4418
DOI: 10.3390/diagnostics11010058
Popis: Pericarditis may signal the presence of cancer, even in the absence of other clinical or paraclinical signs. Corollary, the following question arises: Could the discovery of a newly developed pericarditis be used in patients with known neoplasia as a marker of cancer progression? In an attempt to find an answer to this question, this two-centre study included 341 consecutive patients with a confirmed diagnosis of cancer and evidence of pericardial effusion at echocardiography and/or CT/MRI scan. The patients&rsquo
data were collected retrospectively if they further fulfilled the following inclusion criteria: available medical data from confirmation of pericarditis until evidence of cancer progression or until at least 12 months without progression. The average age of the patients was 62.16 years (22&ndash
86 years), and the study comprised 44.28% males and 55.71% females. All types of the most common neoplasms were represented. The results showed that 85.33% of patients had cancer progression temporally linked to pericarditis. Of these, 41.64% had cancer progression within 18 months after the diagnosis of pericarditis with a median time to progression of 5.03 months, ranging from 0 to 17 months
43.69% had progression within a maximum of 2 months before the diagnosis of pericarditis. Only 14.66% had no cancer progression during the observation period. We concluded that pericarditis could be a sensitive marker of cancer evolution that could be widely used as a follow-up investigation for cancer patients as a marker of progression or recidive.
Databáze: OpenAIRE
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