Feasibility of percutaneous organ biopsy as part of a minimally invasive perinatal autopsy
| Autor: | A. L. Whitehead, G. A. Hackett, Andrew C. G. Breeze, L. Berman, P. A. K. Set, F. A. Jessop, Christoph Lees |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Percutaneous Biopsy Gestational Age Autopsy Context (language use) Sensitivity and Specificity Pathology and Forensic Medicine Fetus medicine Humans Sampling (medicine) Prospective Studies Molecular Biology Ultrasonography Interventional medicine.diagnostic_test business.industry Infant Newborn Gestational age Anatomical pathology Cell Biology General Medicine Surgery Fetal Diseases Feasibility Studies business Infant Premature |
| Zdroj: | Virchows Archiv. 452:201-207 |
| ISSN: | 1432-2307 0945-6317 |
| Popis: | To determine the feasibility of percutaneous fetal organ biopsies in the context of a 'minimally invasive' perinatal autopsy after stillbirth and termination for abnormality is the aim of this study. We assessed successful biopsy rate and the proportion adequate for histological examination in 30 fetuses undergoing organ sampling before autopsy. The relationship between gestational age, body weight, death-biopsy interval, operator experience and successful biopsy rate was investigated. Significant findings from conventional block histology were compared with corresponding percutaneous biopsies. Of 210 organ biopsies attempted from seven target organs, 107 were obtained, of which 94 were adequate for pathological comment. The median delivery-autopsy interval was 4 (range 2-11) days. Adequate samples were obtained from the lung in 86% cases (95% CI 68, 96%), liver 76% (95% CI 56, 90%) and less frequently for the myocardium, kidney, adrenal, thymus and spleen. There was no relationship between biopsy success and time to biopsy, gestational age, body weight and user experience. No histological abnormalities found at autopsy were diagnosed from needle biopsies. Although targeted percutaneous biopsies appear feasible for some organs, fewer than 50% of all biopsies are adequate for histological examination. This technique cannot be considered to provide useful clinical information as part of a 'minimally invasive' perinatal autopsy. |
| Databáze: | OpenAIRE |
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