6,7-Dihydro-4H-indolones: synthesis and biological properties
| Autor: | C. D. Schiller, Martin R. Schneider, E. von Angerer |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Indole test
Male Birch reduction Indoles Stereochemistry Estrogen Antagonists Pharmaceutical Science Biological activity Androgen Antagonists urologic and male genital diseases Antiestrogen Zindoxifene Acylation Androgen receptor chemistry.chemical_compound Mice chemistry Drug Discovery Animals Female Phenols hormones hormone substitutes and hormone antagonists |
| Zdroj: | Archiv der Pharmazie. 324(10) |
| ISSN: | 0365-6233 |
| Popis: | Syntheses of 6,7-dihydro-4H-indolones 6 and 10 by a selective Birch reduction of the benzene ring of the indole system are described. The antiestrogen zindoxifene and the 2-phenylindole 2 as well as 6 and 10 were tested for their relative binding affinities at the androgen receptor as well as for antiandrogenic and estrogenic properties. Both compounds 6 and 10 showed potent indirect antiandrogenic activity which were similar to those of the 2-phenyl-indoles zindoxifene and 2. |
| Databáze: | OpenAIRE |
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