Metabolic manifestations of polycystic ovary syndrome in nonobese adolescents: retinol-binding protein 4 and ectopic fat deposition
| Autor: | Aviva B. Sopher, Donald J. McMahon, Sharon E. Oberfield, Jeremy M. Root, Adrienne T. Gerken, William S. Blaner |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Adolescent medicine.medical_treatment Adipose tissue Pilot Projects Article Body Mass Index Young Adult Insulin resistance Internal medicine medicine Humans Insulin Triglycerides Analysis of Variance Retinol binding protein 4 Glucose tolerance test Adipogenesis biology medicine.diagnostic_test Age Factors Obstetrics and Gynecology Glucose Tolerance Test medicine.disease Polycystic ovary Hormones Cross-Sectional Studies Endocrinology Liver Reproductive Medicine Case-Control Studies biology.protein Female Insulin Resistance Retinol-Binding Proteins Plasma Body mass index Biomarkers Dyslipidemia Polycystic Ovary Syndrome |
| Zdroj: | Fertility and Sterility. 97:1009-1015 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/j.fertnstert.2012.01.111 |
| Popis: | Objective To determine whether nonobese adolescents with polycystic ovary syndrome (PCOS) have higher levels of retinol-binding protein 4 (RBP4) and ectopic fat than controls and whether RBP4 and ectopic fat correlate with comorbidities of metabolic disease. Design Cross-sectional case-control study. Setting Pediatric clinical research center based in a quaternary care medical center. Patient(s) Twenty-four nonobese adolescents between the ages of 13 and 21 years, 13 with PCOS and 11 controls. Intervention(s) Measurement of RBP4, insulin resistance, lipids, and body composition. Main Outcome Measure(s) Retinol-binding protein 4, reproductive and adrenal hormones, insulin resistance, intrahepatic and intramyocellular lipid levels, and visceral adipose tissue. Result(s) Adolescents with PCOS had higher intrahepatic lipid content and a statistical trend for higher RBP4 compared with controls. Retinol-binding protein 4 correlated with body fat, triglycerides, insulin resistance, and androgens but not intrahepatic lipid content; however, when adjusted for body fat, the correlation between RBP4 and triglycerides weakened to a statistical trend and was no longer statistically significant for the other measures. Conclusion(s) This small preliminary study of nonobese adolescent girls suggests that RBP4 may be involved in the dyslipidemia associated with PCOS and that there may be an independent relationship between RBP4 and triglycerides but not between RBP4 and insulin resistance. Although intrahepatic lipid content was higher in PCOS, it did not correlate with RBP4, triglycerides, or insulin resistance. |
| Databáze: | OpenAIRE |
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