Associations of urine metals and metal mixtures during pregnancy with cord serum vitamin D Levels: A prospective cohort study with repeated measurements of maternal urinary metal concentrations
| Autor: | Xingjie Fang, Yongning Wu, Juxiao Li, Shu Huan, Yuanyuan Li, Xiaojie Sun, Shunqing Xu, Jingguang Li, Tongzhang Zheng, Jingyu Qu, Shuna Jin, Qi Liu, Wei Xia |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Urine metals 010504 meteorology & atmospheric sciences Urinary system Physiology Newborns’ vitamin D status Urine 010501 environmental sciences 01 natural sciences vitamin D deficiency Pregnancy Vitamin D and neurology Humans Medicine GE1-350 Prospective Studies Vitamin D Child Prospective cohort study Repeated measurements 0105 earth and related environmental sciences General Environmental Science business.industry Infant Newborn Bayes Theorem Fetal Blood Vitamin D Deficiency medicine.disease Confidence interval Environmental sciences Metals Mixtures Cord blood Female business |
| Zdroj: | Environment International, Vol 155, Iss, Pp 106660-(2021) |
| ISSN: | 0160-4120 |
| Popis: | Background: Vitamin D deficiency has been associated with the increased risk of many diseases, especially during early life. Exposure to some toxic metals may decrease vitamin D levels in adults and children in previous studies. However, less is known about the associations of maternal metals exposure during pregnancy with newborns’ vitamin D status. Objective: We conducted a prospective cohort study to investigate the relationships between urine metals and metal mixtures during pregnancy and newborns’ vitamin D status. Methods: Urine samples of 598 pregnant women were collected in each trimester and cord blood samples of newborns were collected at delivery. The concentrations of 20 metals in urine and 25-hydroxyvitamin D [25(OH)D] in cord serum were quantified. Generalized linear models were used to estimate the associations between individual metals and cord serum total 25(OH)D. We applied Bayesian Kernel Machine Regression (BKMR) to evaluate the mixture and interaction effects of urine metals. Results: In individual metals analyses, we reported that a double increase in urine vanadium (V), cobalt (Co), and thallium (Tl) throughout pregnancy was associated with a 9.91% [95% confidence interval (CI): −18.58%, −0.30%], 11.42% (95% CI: −17.73%, −4.63%), and 12.64% (95% CI: −21.44%, −2.86%) decrease in cord serum total 25(OH)D, respectively. Exposures to the three metals during the whole pregnancy were also correlated to increased odds for newborns’ vitamin D deficiency ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect