Role of Postoperative Radiotherapy in Nonmetastatic Head and Neck Adenoid Cystic Carcinoma
| Autor: | Zi-Qi Zheng, Xiao-Dan Huang, Jian-Ye Yan, Fo-Ping Chen, Feng Li, Yue Chen, Guan-Qun Zhou, Ying Sun |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Multivariate analysis Adenoid cystic carcinoma Postoperative radiotherapy Recursive partitioning Survival outcome Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Port (medical) medicine Humans 030223 otorhinolaryngology Head and neck Neoplasm Staging Retrospective Studies Univariate analysis business.industry medicine.disease Salivary Gland Neoplasms Carcinoma Adenoid Cystic Survival Rate Oncology Head and Neck Neoplasms 030220 oncology & carcinogenesis Radiology Neoplasm Recurrence Local business |
| Zdroj: | Journal of the National Comprehensive Cancer Network : JNCCN. 18(11) |
| ISSN: | 1540-1413 |
| Popis: | Background: Head and neck adenoid cystic carcinoma (ACC) is a rare malignant tumor that is prone to local recurrence. The NCCN Guidelines for Head and Neck Cancers recommend that all patients with ACC receive postoperative radiotherapy (PORT). However, whether PORT can improve local control and which patients can benefit from PORT are unknown. This study aimed to assess the role of PORT and provide individualized suggestions for postoperative therapy in patients with ACC. Patients and Methods: We retrospectively reviewed patients with nonmetastatic head and neck ACC who underwent surgery with or without PORT. Recursive partitioning analysis (RPA) was performed to categorize the patients and predict local recurrence-free survival (LRFS). The survival outcome was compared between non-PORT and PORT groups. Results: A total of 319 patients were included. PORT was identified as a prognostic factor for LRFS in univariate (P=.01) and multivariate analysis (PPPP=.10). Conclusions: PORT was shown to be a positive prognostic factor for improved LRFS in ACC. Furthermore, PORT could significantly improve LRFS in intermediate-risk and high-risk patients with ACC, but whether low-risk patients could benefit from PORT needs further study. |
| Databáze: | OpenAIRE |
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