Serum Bioactive and Immunorective Follicle Stimulating Hormone During Chronic Treatment with Gonadotropin Releasing Hormone Agonist in Elderly Men
| Autor: | Z. Braf, H. Matzkin, Nava Dekel |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Agonist endocrine system medicine.medical_specialty Time Factors medicine.drug_class Endocrinology Diabetes and Metabolism Granulosa cell Clinical Biochemistry Prostatic Hyperplasia Biochemistry Muscle hypertrophy Gonadotropin-Releasing Hormone Follicle-stimulating hormone Endocrinology Internal medicine Gonadotropin-releasing hormone agonist medicine Animals Humans Bioassay Cells Cultured Aged Analysis of Variance Granulosa Cells Triptorelin Pamoate business.industry Biochemistry (medical) General Medicine Middle Aged Rats Luteolytic Agents Regression Analysis Biological Assay Female Follicle Stimulating Hormone Gonadotropin business hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Hormone and Metabolic Research. 23:76-80 |
| ISSN: | 1439-4286 0018-5043 |
| DOI: | 10.1055/s-2007-1003618 |
| Popis: | Chronic administration of GnRH agonists "down regulates" the pituitary and decreases LH and FSH serum levels. Changes in the bioactivity of FSH have not been adequately assessed under such treatment, for lack of a proper test. We examined serum changes under GnRH agonist treatment among 12 healthy elderly men suffering only from benign prostatic hypertrophy, for up to one year, using a modification of a granulosa cell bioassay for the determination of FSH bioactivity. While radioimmunoassay-FSH decreased, we noticed a significant increase in the bioactivity of this hormone. The clinical importance of this increase is discussed. |
| Databáze: | OpenAIRE |
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