Accelerated bone regeneration through rational design of magnesium phosphate cements

Autor:	Friederike Kaiser, Lena Schröter, Svenja Stein, Benjamin Krüger, Jan Weichhold, Philipp Stahlhut, Anita Ignatius, Uwe Gbureck
Rok vydání:	2022
Předmět:	Calcium Phosphates Bone Regeneration Sheep Struvite Bone Cements Biomedical Engineering Magnesium Compounds General Medicine Biochemistry Phosphates Biomaterials Bone Substitutes Materials Testing Animals Powders Molecular Biology Biotechnology
Zdroj:	Acta Biomaterialia. 145:358-371
ISSN:	1742-7061
Popis:	Results of several studies during past years suggested that magnesium phosphate cements (MPCs) not only show excellent biocompatibility and osteoconductivity, but they also provide improved regeneration capacity due to higher solubility compared to calcium phosphates. These findings also highlighted that chemical similarity of bone substitutes to the natural bone tissue is not a determinant factor in the success of regenerative strategies. The aim of this study was to further improve the degradation speed of MPCs for a fast bone ingrowth within a few months. We confirmed our hypothesis, that decreasing the powder-liquid ratio (PLR) of cement results in an increased content of highly soluble phases such as struvite (MgNH
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1769bc4824325bc9a847c0f8537fb3d3 https://doi.org/10.1016/j.actbio.2022.04.019 Zobrazit plný text záznamu Full Text from ScienceDirect