Is left-sided involvement of hepatocellular carcinoma an important preoperative predictive factor of poor outcome?
| Autor: | Taku Aoki, Kyung Hwa Park, Keiichi Kubota, Kazuma Tago, Shozo Mori, Takayuki Shiraki, Genki Tanaka, Takatsugu Matsumoto, Yukihiro Iso, Yuhki Sakuraoka, Takayuki Shimizu |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Liver surgery
medicine.medical_specialty Carcinoma Hepatocellular Hepatocellular carcinoma lcsh:Surgery Left sided Gastroenterology lcsh:RC254-282 Disease-Free Survival 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Surgical oncology Internal medicine medicine Hepatectomy Humans business.industry Research Liver Neoplasms lcsh:RD1-811 medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Prognosis Predictive factor Oncology chemistry 030220 oncology & carcinogenesis Laterality 030211 gastroenterology & hepatology Surgery business Alpha-fetoprotein Indocyanine green |
| Zdroj: | World Journal of Surgical Oncology World Journal of Surgical Oncology, Vol 18, Iss 1, Pp 1-9 (2020) |
| ISSN: | 1477-7819 |
| Popis: | Background The tumor location is the most simple clinical factor and important in liver surgery to make surgical procedure. However, no previous study has investigated the prognostic differences and clinical features of hepatocellular carcinoma showing specific laterality. This study is the first report to focus on the laterality and aimed to lead to more simple and useful predictive factor rather than recent complicated predictive models. Methods Patients who underwent liver resection for the first time for single tumors located within each lobe between 2000 and 2018 were enrolled. We divided them into two groups based on tumor location: a right-sided group and a left-sided group. Univariable and multivariable analyses were performed to assess survival differences in relation to several other factors. Results There were 595 eligible patients; the 5-year survival rates and disease-free survival rates were 49.5% and 19.1% in the left-sided group and 55.6% and 24.5% in the right-sided group, respectively (p = 0.026). Statistical analyses revealed that the following preoperative prognostic factors were independently significant (p < 0.05) in the left-sided group: indocyanine green retention rate at 15 min, alpha fetoprotein, protein induced by vitamin K absence or antagonists-II level, and larger tumor size. Conclusion The left-sided group had a poorer prognosis than the right-sided group. A left-sided tumor location is a significant preoperative factor predictive of poor outcome in patients with hepatocellular carcinoma. |
| Databáze: | OpenAIRE |
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