Association of endogenous sex hormone with C-reactive protein levels in middle-aged and elderly men
Autor: | Hamid Reza Nakhai Pour, Diederick E. Grobbee, Majon Muller, Yvonne T. van der Schouw |
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Přispěvatelé: | Internal medicine, ACS - Atherosclerosis & ischemic syndromes |
Jazyk: | angličtina |
Rok vydání: | 2007 |
Předmět: |
Male
Aging medicine.medical_specialty Endocrinology Diabetes and Metabolism chemistry.chemical_compound Endocrinology Dehydroepiandrosterone sulfate Sex hormone-binding globulin Risk Factors Sex Hormone-Binding Globulin Internal medicine medicine Humans Testosterone Prospective Studies Prospective cohort study Aged Aged 80 and over Inflammation Estradiol biology Dehydroepiandrosterone Sulfate C-reactive protein Acute-phase protein Middle Aged Middle age C-Reactive Protein Quartile chemistry Cardiovascular Diseases Multivariate Analysis Linear Models biology.protein Biomarkers Hormone |
Zdroj: | Clinical Endocrinology, 66(3), 394-398. Wiley-Blackwell Pour, H R N, Grobbee, D E, Muller, M & Van Der Schouw, Y T 2007, ' Association of endogenous sex hormone with C-reactive protein levels in middle-aged and elderly men ', Clinical Endocrinology, vol. 66, no. 3, pp. 394-398 . https://doi.org/10.1111/j.1365-2265.2007.02745.x |
ISSN: | 0300-0664 |
Popis: | Summary Background In women, postmenopausal oestrogen supplementation increases levels of systemic markers of inflammation, which are important predictors of coronary heart disease (CHD) risk. Whether endogenous sex hormone levels in men are also related to systemic subclinical inflammation is still unknown. Objective We tested the hypothesis that higher endogenous sex hormones levels within the physiological range may be associated with systemic subclinical inflammation. Methods Circulating sex hormone and high-sensitivity C-reactive protein (hs-CRP) levels were determined in 400 apparently healthy men aged between 40 and 80 years. We used multivariate linear regression analysis with the various sex hormones as determinant, and natural log hs-CRP as outcome. Results Higher levels of total as well as bioavailable oestradiol (E2) were associated with increased natural log hs-CRP levels, which remained statistically significant after adjustment for age and cardiovascular risk factors. Natural log hs-CRP was 0·26 mg/l higher [95% confidence interval (CI) −0·02 to 0·54] in the fourth than in the first quartile of total E2; the P-value for linear trend was 0·05. For bioavailable E2, the difference in natural log hs-CRP between the fourth and the first quartile was 0·30 mg/l (95% CI 0·03–0·56; P-value for linear trend 0·04). After adjustment for age and cardiovascular risk factors, physiological levels of total (TT) or bioavailable testosterone or dehydroepiandrosterone sulfate (DHEAS) were not associated with hs-CRP. Conclusion Endogenous total and bioavailable E2 levels are significantly associated with CRP among middle-aged and elder men. |
Databáze: | OpenAIRE |
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