Frequency Content of Cartilage Impact Force Signal Reflects Acute Histologic Structural Damage
| Autor: | Daniel R. Thedens, Jessica E. Goetz, Anneliese D. Heiner, Todd O. McKinley, Thomas D. Brown, James A. Martin |
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| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty posttraumatic osteoarthritis impact testing 0206 medical engineering Biomedical Engineering Stress rate Physical Therapy Sports Therapy and Rehabilitation 02 engineering and technology Signal Article histology 03 medical and health sciences 0302 clinical medicine medicine Immunology and Allergy articular cartilage impact injury 030203 arthritis & rheumatology business.industry Cartilage Mechanical impact Articular surface 020601 biomedical engineering Frequency spectrum medicine.anatomical_structure Impact energy Impact business Biomedical engineering |
| Zdroj: | Cartilage |
| ISSN: | 1947-6043 1947-6035 |
| Popis: | Objective: The objective of this study was to determine if acute cartilage impact damage could be predicted by a quantification of the frequency content of the impact force signal. Design: Osteochondral specimens excised from bovine lateral tibial plateaus were impacted with one of six impact energies. Each impact force signal underwent frequency analysis, with the amount of higher-frequency content (percentage of frequency spectrum above 1 kHz) being registered. Specimens were histologically evaluated to assess acute structural damage (articular surface cracking and cartilage crushing) resulting from the impact. Results: Acute histologic structural damage to the cartilage had higher concordance with the high-frequency content measure than with other mechanical impact measures (delivered impact energy, impact maximum stress, and impact maximum stress rate of change). Conclusions: This result suggests that the frequency content of an impact force signal, specifically the proportion of higher-frequency components, can be used as a quick surrogate measure for acute structural cartilage injury. Taking advantage of this relationship could reduce the time and expense of histologic processing needed to morphologically assess cartilage damage, especially for purposes of initial screening when evaluating new impaction protocols. |
| Databáze: | OpenAIRE |
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