Iron, Atherosclerosis, and Neurodegeneration: A Key Role for Cholesterol in Promoting Iron-Dependent Oxidative Damage?
| Autor: | Wei-Yi Ong, Barry Halliwell |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Statin Arteriosclerosis medicine.drug_class Iron Blood–brain barrier General Biochemistry Genetics and Molecular Biology Oxidative damage chemistry.chemical_compound History and Philosophy of Science Internal medicine medicine Increased iron Animals Humans chemistry.chemical_classification business.industry Cholesterol Mechanism (biology) General Neuroscience Neurodegeneration Brain Neurodegenerative Diseases medicine.disease Oxidative Stress medicine.anatomical_structure Endocrinology chemistry Transferrin business |
| Zdroj: | Annals of the New York Academy of Sciences. 1012:51-64 |
| ISSN: | 1749-6632 0077-8923 |
| Popis: | This article reviews the roles and interactions of iron, atherosclerosis, and neurodegeneration. It highlights the importance of cholesterol in promoting iron-dependent oxidative damage. An intriguing possibility is that hypercholesterolemia can increase brain iron load and both the aggregation of beta-amyloid and the ability of iron on plaques to catalyze oxidative damage. This could explain why hypercholesterolemia is a risk factor for Alzheimer's disease. Further work is necessary to study the mechanism of increased iron transport across the blood brain barrier in atherosclerosis. |
| Databáze: | OpenAIRE |
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