Dopamine Modulates Episodic Memory Persistence in Old Age
| Autor: | Raymond J. Dolan, Marc Guitart-Masip, Emrah Düzel, Nico Bunzeck, Rumana Chowdhury |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Aging Levodopa drug effects [Hippocampus] Dopamine Memory Episodic Dopamine Agents physiology [Hippocampus] Hippocampus Hippocampal formation Article Cohort Studies methods [Magnetic Resonance Imaging] Double-Blind Method physiology [Dopamine] medicine Humans ddc:610 pharmacology [Levodopa] Episodic memory Aged Cross-Over Studies Dose-Response Relationship Drug Long-term memory General Neuroscience Dopaminergic FLASH MRI physiology [Aging] Magnetic Resonance Imaging drug effects [Aging] pharmacology [Dopamine Agents] methods [Photic Stimulation] Female Psychology Neuroscience Photic Stimulation medicine.drug |
| Zdroj: | The Journal of Neuroscience The journal of neuroscience 32(41), 14193-14204 (2012). doi:10.1523/JNEUROSCI.1278-12.2012 |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.1278-12.2012 |
| Popis: | Activation of the hippocampus is required to encode memories for new events (or episodes). Observations from animal studies suggest that, for these memories to persist beyond 4–6 h, a release of dopamine generated by strong hippocampal activation is needed. This predicts that dopaminergic enhancement should improve human episodic memory persistence also for events encoded with weak hippocampal activation. Here, using pharmacological functional MRI (fMRI) in an elderly population in which there is a loss of dopamine neurons as part of normal aging, we show this very effect. The dopamine precursor levodopa led to a dose-dependent (inverted U-shape) persistent episodic memory benefit for images of scenes when tested after 6 h, independent of whether encoding-related hippocampal fMRI activity was weak or strong (U-shaped dose–response relationship). This lasting improvement even for weakly encoded events supports a role for dopamine in human episodic memory consolidation, albeit operating within a narrow dose range. |
| Databáze: | OpenAIRE |
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