Estimation of 123I-IMP arterial blood activity from dynamic planar imaging of the chest using a graph plot method for the quantification of regional cerebral blood flow
| Autor: | Tsutomu Soma, Morikatsu Yoshida, Koichi Kawanaka, Yasuyuki Yamashita, Yoshitake Takahashi, Seiji Tomiguchi, Shinya Shiraishi, Kuniyuki Tashiro |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Time Factors Planar Imaging 123i imp Plot (graphics) Injections Microsphere mental disorders Humans Medicine Radiology Nuclear Medicine and imaging Arterial input function cardiovascular diseases 123I-IMP Lung Aged business.industry Reproducibility of Results Arteries General Medicine Middle Aged Thorax Iofetamine Molecular Imaging nervous system Cerebral blood flow Cerebrovascular Circulation arterial input function Regression Analysis Arterial blood Female biological phenomena cell phenomena and immunity CBF measurement Pulmonary dynamic imaging business Nuclear medicine circulatory and respiratory physiology Blood sampling |
| Zdroj: | Annals of Nuclear Medicine. 24:387-393 |
| ISSN: | 1864-6433 0914-7187 |
| DOI: | 10.1007/s12149-010-0370-1 |
| Popis: | Purpose: I-123 labeled N-isopropyl-p-iodoamphetamine(123I-IMP) is used for measurement of regional cerebral blood flow(rCBF). A continuous or single arterial blood sampling(ABS) is necessary to estimate an integral of arterial input function(AIF) for the measurement of rCBF by using a microsphere model analysis. Therefore, the method to measure rCBF without any blood sampling is desired. The aim of this study was to establish the method to estimate the AIF from the time-activity curve of the lungs after the injection of 123I-IMP using a regression analysis for the measurement of rCBF without any blood sampling. Materials and methods: Thirty-seven prospective studies in 10 consecutive patients were enrolled. A chest planar dynamic imaging for 3 minutes and continuous ABS for 5 minutes after a bolus injection of 167MBq 123I-IMP were performed in all studies. Data from the chest imaging were analyzed in comparison with ABS data(AIF(5)) in the first 10 studies, and an equation for estimation yielding accurate AIF(5) from the total counts cleared from the lungs during 5 minutes after injection of 123I-IMP(TCL(5)) was derived. The validity of the proposed method was evaluated in the subsequent 27 studies.Results: A good correlation was obtained between the AIF and TCL by regression analysis in the first 10 studies(r=0.94, p |
| Databáze: | OpenAIRE |
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