Cellular Immune Responsiveness of Uveitis Patients to Retinal S-Antigen
| Autor: | Elmer J. Ballintine, Robert B. Nussenblatt, W B Wacker, Igal Gery |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Adult
Male Disease Lymphocyte Activation Retina Antigen-Antibody Reactions Uveitis Pathogenesis chemistry.chemical_compound Immune system Retinal Diseases Antigen medicine Humans Antigens Aged Immunity Cellular business.industry Retinal Middle Aged medicine.disease Control subjects Ophthalmology Retinal s antigen chemistry Immunology Female business |
| Zdroj: | American Journal of Ophthalmology. 89:173-179 |
| ISSN: | 0002-9394 |
| DOI: | 10.1016/0002-9394(80)90108-7 |
| Popis: | S-antigen, an organ-specific substance isolated from the retinal photoreceptor region, was shown to be a potent agent for the induction of experimental autoimmune uveitis. S-antigen and other ocular antigens were tested for their ability to induce blast transformation of lymphocytes from patients with a variety of ocular inflammatory diseases. Lymphocytes from 22% of patients tested manifested a positive memory response to the S-antigen prepared from bovine eyes. Responses to human S-antigen paralleled those found with the bovine. All of those with a positive response had active or inactive retinal lesions. Some posterior uveitis patients responded to crude retinal extracts but not to S-antigen, indicating the possible role of other retinal antigens still to be purified. Control subjects did not manifest a positive immune response to the S-antigen, nor did patients with anterior uveitis. Possibly, these responses play some role in the pathogenesis of the disease. |
| Databáze: | OpenAIRE |
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