The small G-protein RalA stimulates metastasis of transformed cells
| Autor: | Elena M. Tchevkina, Anna Martinjuk, Andrei Komelkov, Natalya Dyakova, Larisa Agapova, A. G. Tatosyan |
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| Rok vydání: | 2004 |
| Předmět: |
Cancer Research
medicine.medical_specialty G protein Small G Protein Endogeny Biology medicine.disease_cause Models Biological Metastasis Cricetinae Internal medicine Genetics medicine Animals Neoplasm Metastasis Molecular Biology Cell Line Transformed DNA Primers Base Sequence Mesocricetus dGTPase Fibroblasts Embryo Mammalian medicine.disease RALA Disease Models Animal Cell Transformation Neoplastic Endocrinology Cancer research ral GTP-Binding Proteins Signal transduction Carcinogenesis |
| Zdroj: | Oncogene. 24:329-335 |
| ISSN: | 1476-5594 0950-9232 |
| DOI: | 10.1038/sj.onc.1208094 |
| Popis: | RAS oncogenes play a critical role in oncogenic transformation and metastases formation. Here we show that Ha-ras greatly stimulates spontaneous metastatic activity of transformed cells through the Ras/RalGDS/RalA intracellular signaling pathway. Introduction of RalA alone leads to a drastic increase of metastatic activity of transformed cells. We demonstrate that metastatic ability of cells could be dramatically enhanced by RalA stimulation or, conversely, hampered by RalA suppression. Furthermore, we found that during in vivo selection cells acquire high metastatic properties as a result of endogenous RalA activation. The ability of RalA to induce metastasis was demonstrated in spontaneously transformed as well as in virus transformed fibroblasts. |
| Databáze: | OpenAIRE |
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