Salvia officinalis mitigates uterus and liver damages induced by an estrogen deficiency in ovariectomized rats
| Autor: | Fatma Makni-Ayadi, Mouna Turki, Fatma Koubaa-Ghorbel, Hajer Jdidi, Mariem Chaâbane, Abdelfattah El Feki |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
030309 nutrition & dietetics medicine.drug_class Ovariectomy Biophysics Uterus medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology food Internal medicine Medicine Animals Humans Rats Wistar Salvia officinalis Pharmacology 0303 health sciences Glycogen business.industry Estrogens 04 agricultural and veterinary sciences Cell Biology medicine.disease 040401 food science food.food Rats Menopause medicine.anatomical_structure Endocrinology chemistry Liver Estrogen Ovariectomized rat Female medicine.symptom business Weight gain Oxidative stress Food Science |
| Zdroj: | Journal of food biochemistryREFERENCES. 45(5) |
| ISSN: | 1745-4514 |
| Popis: | The present study evaluated the antioxidant activity of Salvia officinalis (sage) and its protective effect on estrogen deficiency in ovariectomized rats. Female Wistar rats were treated during either 15 or 30 days as follows: group C: negative controls, group S: positive controls treated with sage leaves, ovariectomized rats (group OVX) and ovariectomized rats receiving either sage (OVX-S) or hormonal (Group OVX-E) treatments, respectively. After 15 and 30 days of treatments, OVX rats showed a gain in body weight and an increase of absolute and relative liver weights. Meanwhile, absolute and relative uterus weights were decreased. Moreover, ovariectomy altered plasma transaminases' activities, lipid profile, and disrupted the redox status of liver and uterine tissues. It affected also the reproductive tract by decreasing the uterus glycogen content and plasma LDH activity. Supplementation of sage via the diet reduced weight gain and oxidative stress resulting from estrogen deficiency. PRACTICAL APPLICATIONS: During menopause, sexual hormone deficiency, especially estrogen, causes several morphological and physiological disturbances in liver and uterus tissues. In fact, the body weight gain and disturbances of redox status in liver and uterus were the main health problems detected after menopause. Sage leaves, used as medicinal plant, exerted its beneficial effects in the management of menopause disorders. As an important source of antioxidants, sage leaves could prevent obesity and oxidative damage in the liver and uterus resulting from estrogen deficiency. |
| Databáze: | OpenAIRE |
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