Marked Reduction of the Number and Individual Volume of Sebaceous Glands in Psoriatic Lesions
| Autor: | Evgenia Makrantonaki, Stefanos Bonovas, Juergen Knolle, Christos C. Zouboulis, Jens R. Nyengaard, Aikaterini I. Liakou |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Sebaceous gland Adult Male medicine.medical_specialty Biopsy Inflammation Dermatology Severity of Illness Index Desquamation 030207 dermatology & venereal diseases 03 medical and health sciences Sebaceous Glands 0302 clinical medicine Imaging Three-Dimensional Psoriasis medicine Humans Parakeratosis Aged Skin medicine.diagnostic_test integumentary system business.industry Alopecia Middle Aged medicine.disease Immunohistochemistry Sebum 030104 developmental biology medicine.anatomical_structure Female medicine.symptom business Infiltration (medical) |
| Zdroj: | Liakou, A I, Nyengaard, J R, Bonovas, S, Knolle, J, Makrantonaki, E & Zouboulis, C C 2016, ' Marked Reduction of the Number and Individual Volume of Sebaceous Glands in Psoriatic Lesions ', Dermatology, vol. 232, no. 4, pp. 415-424 . https://doi.org/10.1159/000445942 |
| ISSN: | 1421-9832 |
| DOI: | 10.1159/000445942 |
| Popis: | Background: Psoriasis is a chronic inflammatory skin disease characterized by plaques with inflammation, infiltration, hyper-/parakeratosis and desquamation. Microscopic findings in previous studies have revealed some degree of atrophy of the sebaceous glands in patients with psoriasis vulgaris and psoriatic alopecia. Objective: The aim of this study was to investigate possible changes of the sebaceous glands in patients with psoriatic plaques and especially psoriatic alopecia. Methods: Histological and stereological analyses were performed in skin specimens from involved and healthy-looking skin of 14 patients with psoriasis. Stereology detects and quantifies 3-dimensional structures ex vivo. Furthermore, the differentiation process of sebocytes of another 14 psoriatic patients was examined by immunohistochemistry of involved and uninvolved skin specimens. Results: A significant reduction of the number of sebaceous glands as well as of the volume of individual sebaceous glands was assessed in the lesional compared to the nonlesional psoriatic skin. Moreover, it was likely that sebocytes in psoriatic lesions may not differentiate properly. Conclusion: These findings indicate that the sebaceous gland may be a player and not an innocent bystander in the development of psoriatic lesions and especially of psoriatic alopecia. |
| Databáze: | OpenAIRE |
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