Specific inhibition of hypothalamic self-stimulation by selective reuptake blockade of either 5-hydroxytryptamine or noradrenaline
| Autor: | T. Ljungberg, Dale M. Atrens, Urban Ungerstedt |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
Serotonin medicine.medical_specialty Pharmacology toxicology Hypothalamus Stimulation Thiophenes Pharmacology Reuptake Bridged Bicyclo Compounds Norepinephrine Self Stimulation Internal medicine medicine Animals 5-HT receptor Benzofurans Chemistry Highly selective Electrodes Implanted Rats Blockade Endocrinology Depression Chemical Thymoleptics |
| Zdroj: | Psychopharmacology. 52:177-180 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/bf00439106 |
| Popis: | The effects of two new phthalane-derived bicyclic thymoleptics on hypothalamic self-stimulation were investigated in rats. The drugs, LU 10-171 and LU 5-003 are potent and highly selective reuptake blockers of 5-hydroxytryptamine (5-HT) and noradrenaline (NA), respectively. The use of a two-way shuttle-box permitted the differentiation of specific reward modulation effects from the variety of non-specific performance changes that these drugs may produce. Selective reuptake blockade of either 5HT or NA produced a dose-dependent reduction in reward that could be clearly dissociated from any non-specific performance decrements. Besides providing direct evidence for a significant role for 5HT in the mediation of hypothalamic self-stimulation, these data show that symphy increasing transmitter availability is not a sufficient condition to enhance self-stimulation reward. It is suggested that self-stimulation is dependent on response-contingent transmitter release and that any operation that increases reward-transmitter availability in a response-independent manner should attenuate self-stimulation. |
| Databáze: | OpenAIRE |
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