Chronic urticaria in the real‐life clinical practice setting in the UK: results from the noninterventional multicentre AWARE study

Autor:	Sinisa Savic, Anthony Bewley, S. Marinho, A. Marsland, Ravishankar Sargur, Lucy Leeman, T. El‐Shanawany, R. Randall, O. Somenzi, Alla Nakonechna, J. E. Gach, N. Fragkas, Robert Ellis, S. Wahie
Rok vydání:	2020
Předmět:	Adult Male medicine.medical_specialty Comorbidity Efficiency Omalizumab Dermatology Severity of Illness Index Body Mass Index 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Cost of Illness Quality of life Internal medicine Activities of Daily Living Anti-Allergic Agents Humans Medicine Chronic Urticaria Patient Reported Outcome Measures Prospective Studies Angioedema Depression (differential diagnoses) Asthma business.industry Dermatology Life Quality Index Middle Aged medicine.disease United Kingdom Discontinuation 030220 oncology & carcinogenesis Cyclosporine Histamine H1 Antagonists Quality of Life Health Resources Anxiety Female medicine.symptom business Body mass index Immunosuppressive Agents
Zdroj:	Savic, S, Leeman, L, El-shanawany, T, Ellis, R, Gach, J E, Marinho, S, Wahie, S, Sargur, R, Bewley, A P, Nakonechna, A, Randall, R, Fragkas, N, Somenzi, O & Marsland, A 2020, ' Chronic urticaria in the real-life clinical practice setting in the UK: results from the non-interventional multicentre AWARE study ', Clinical and Experimental Dermatology . https://doi.org/10.1111/ced.14230
ISSN:	1365-2230 0307-6938
DOI:	10.1111/ced.14230
Popis:	Background Chronic urticaria (CU) is a skin condition characterised by repeated occurrence of itchy wheals and/or angioedema for >6 weeks. Aim To provide data demonstrating the real‐life burden of CU in the UK. Methods This UK subset of the worldwide, prospective, non‐interventional AWARE study included patients aged 18–75 years diagnosed with H1‐antihistamine (H1‐AH)‐refractory chronic spontaneous urticaria (CSU) for >2 months. Baseline characteristics, disease activity, treatments, comorbidities and healthcare resource use were documented. Quality of life, work productivity and activity impairment were assessed. Results Baseline analysis included 252 UK patients. Mean age and body mass index were 45.0 years and 29.0 kg/m2, respectively. Most patients were female (77.8%) and had moderate/severe disease activity (mean Urticaria Activity Score over 7 days, 18.4) and a ‘spontaneous’ component to their CU (73.4% CSU; 24.6% CSU and chronic inducible urticaria). Common comorbidities included depression/anxiety (24.6%), asthma (23.8%) and allergic rhinitis (12.7%). A previous treatment was recorded for 57.9% of patients. Mean Dermatology Life Quality Index score was 9.5 and patients reported impairments in work productivity and activity. Healthcare resource use was high. Severity of CSU was associated with gender, obesity, anxiety and diagnosis. Only 28.5% of patients completed all nine study visits, limiting analysis of long‐term treatment patterns and disease impact. Conclusions Adult H1‐AH‐refractory CU patients in the UK reported high rates of healthcare resource use and impairment in quality of life, work productivity and activity at baseline. The differing structures of UK healthcare may explain the high study discontinuation rates versus other countries.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175c755bf8bf647a7b44ac56b7528043 https://doi.org/10.1111/ced.14230 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.