Placental type alkaline phosphatase tissue expression in ovarian serous carcinoma

Autor: Maria Orsaria, Laura Mariuzzi, Ambrogio P. Londero, Carla Di Loreto, Diego Marchesoni, Stefania Marzinotto
Rok vydání: 2017
Předmět:
0301 basic medicine
Oncology
Cancer Research
PLAP
endocrine system diseases
CA125
HE4
ovarian serous cancer
prognostic factors
survival
0302 clinical medicine
Ovarian carcinoma
Ovarian Neoplasms
Tissue microarray
General Medicine
Middle Aged
Prognosis
Epididymis
Immunohistochemistry
female genital diseases and pregnancy complications
Isoenzymes
Serous fluid
medicine.anatomical_structure
030220 oncology & carcinogenesis
embryonic structures
Disease Progression
Alkaline phosphatase
Female
Ovarian Serous Carcinoma
medicine.medical_specialty
GPI-Linked Proteins
03 medical and health sciences
WAP Four-Disulfide Core Domain Protein 2
Internal medicine
Genetics
medicine
Humans
Neoplasm Staging
Retrospective Studies
business.industry
Membrane Proteins
Proteins
Cancer
Alkaline Phosphatase
medicine.disease
Cystadenocarcinoma
Serous
030104 developmental biology
Tissue Array Analysis
CA-125 Antigen
Cancer research
business
Zdroj: Cancer Biomarkers. 17:479-486
ISSN: 1875-8592
1574-0153
DOI: 10.3233/cbm-160665
Popis: Objective To analyze the expression profile of placental type alkaline phosphatase (PLAP), cancer antigen 125 (CA125), and human epididymis protein 4 (HE4) in serous ovarian cancer and to correlate their expression with the tumor aggressiveness and progression. Methods Retrospective study considering a tissue microarray of 82 women affected by ovarian serous cancer. Protein expression was assessed by immunohistochemistry on ovarian serous cancer tissue samples. Immunohistochemical staining was semiquantitatively evaluated as H-score. Results Median H-score values were lower for PLAP, 1 (IQR 0-4) than CA125, 10 (IQR 6-12) or HE4, 8 (IQR 5-12). Even if PLAP was less expressed in the cells of serous ovarian cancer than CA125 or HE4 it was relatively more expressed in the fourth quartile of its H-score distribution among cases with low CA125 or HE4 expression. Furthermore, PLAP and HE4 high expression resulted to be significantly correlated with a better prognosis. Conclusions PLAP could be an additional marker for early detection of serous ovarian carcinoma, together with the established CA125 and HE4. In addition, PLAP expression is correlated with prognosis, giving, in this way, an additional tool for improving treatment approach.
Databáze: OpenAIRE
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