Insulinogenic index at 15 min as a marker of nutritional rehabilitation in anorexia nervosa
| Autor: | Tetsuro Naruo, Daisuke Yasuhara, Tetsuro Muranaga, Muneki Tanaka, Shin-ichi Nozoe, Nobuatsu Nagai |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty Anorexia Nervosa Calorie medicine.medical_treatment Nutritional Status Medicine (miscellaneous) Physiology Anorexia nervosa Body Mass Index Internal medicine medicine Humans Insulin Analysis of Variance Glucose tolerance test Nutrition and Dietetics medicine.diagnostic_test business.industry Body Weight Glucose Tolerance Test medicine.disease Obesity Treatment Outcome Endocrinology Area Under Curve Case-Control Studies Female medicine.symptom business Body mass index Weight gain Blood sampling |
| Zdroj: | The American Journal of Clinical Nutrition. 77:292-299 |
| ISSN: | 0002-9165 |
| Popis: | Background: Insulin responses to the oral-glucose-tolerance test (OGTT) in anorexia nervosa (AN) are related to body weight and show various patterns. Although weight gain is a key indicator of a successful nutritional program, it is not a sufficiently accurate index for assessing nutritional status, especially in the periods of marked fear of obesity, because patients often manipulate body weight measurements. Objective: The aim of this study was to determine the relation between insulin metabolism during the early phase of the OGTT and progress (weekly weight gain) during nutritional rehabilitation. Design: Forty-eight inpatients with AN (25 AN restricting type and 23 AN bulimic type) underwent the OGTT, with additional blood sampling at 15 min, when energy intake reached 6694 kJ/d (1600 kcal/d). Thirteen healthy volunteers were also studied. To evaluate early-phase insulin metabolism, we calculated the insulinogenic index after 15 (II 15 min ) and 30 min. On the basis of weekly changes in body weight, the AN participants were divided into good (≥ 0.5 kg) and poor (< 0.5 kg) responders. Results: Among the AN patients, 48% were poor responders. Analysis of variance showed significant differences in the II 15 min values (P = 0.0005) and showed that II 15 min values for good responders were significantly higher than those for the other groups. Conclusions: These findings suggest that a lack of progress in weight gain is frequently observed in AN and that II 15 min values may be a useful marker with which to assess the weekly progress during nutritional rehabilitation. Am J Clin Nutr 2003;77:292‐9. |
| Databáze: | OpenAIRE |
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