Beta-globin gene cluster haplotypes and alpha-thalassemia in sickle cell disease patients from Trinidad
| Autor: | Marc Romana, Erskine Smith, Lisiane Kéclard, Altheia Jones-Lecointe, Marie-Georges Gilbert, C. Saint-Martin, Waveney P. Charles |
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| Přispěvatelé: | Biologie Intégrée du Globule Rouge (BIGR (UMR_S_1134 / U1134)), Institut National de la Transfusion Sanguine [Paris] (INTS)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Université des Antilles (UA)-Université de Paris (UP) |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Genetic Markers Male Thalassemia β globin gene Disease Anemia Sickle Cell Biology Disease cluster 03 medical and health sciences 0302 clinical medicine Gene Frequency alpha-Thalassemia Genetics medicine Humans Gene Allele frequency Ecology Evolution Behavior and Systematics 030304 developmental biology 0303 health sciences Caribbean island Haplotype virus diseases [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology medicine.disease Globins Trinidad and Tobago [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics Haplotypes Anthropology Multigene Family Mutation Female Anatomy Gene Deletion 030215 immunology |
| Zdroj: | American Journal of Human Biology American Journal of Human Biology, Wiley, 2008, 20 (3), pp.342-344. ⟨10.1002/ajhb.20732⟩ |
| ISSN: | 1520-6300 1042-0533 |
| DOI: | 10.1002/ajhb.20732⟩ |
| Popis: | International audience; In this study, we have determined the frequency of beta(S) haplotypes in 163 sickle cell disease patients from Trinidad. The alpha(3.7) globin gene deletion status was also studied with an observed gene frequency of 0.17. Among the 283 beta(S) chromosomes analyzed, the Benin haplotype was the most prevalent (61.8%) followed by Bantu (17.3%), Senegal (8.5%), Cameroon (3.5%), and Arab-Indian (3.2%), while 5.7% of them were atypical. This beta(S) haplotypes distribution differed from those previously described in other Caribbean islands (Jamaica, Guadeloupe, and Cuba), in agreement with the known involvement of the major colonial powers (Spain, France, and Great Britain) in the slave trade in Trinidad and documented an Indian origin of the beta(S) gene. |
| Databáze: | OpenAIRE |
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