Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice
| Autor: | Marcelo Rubinstein, Tamara J. Phillips, Michele A. Kelly, Malcolm J. Low |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_treatment drug response Ciencias de la Salud Pharmacology animal behavior Methamphetamine Behavioral Neuroscience chemistry.chemical_compound Mice LOCOMOTOR ACTIVITY 8 chloro 2 3 4 5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate Sensitization Mice Knockout SCH-23390 Mus article Receptor antagonist SENSITIZATION locomotion medicine.anatomical_structure Neurology priority journal Dopamine receptor Female purl.org/becyt/ford/3 [https] Psychology medicine.drug CIENCIAS MÉDICAS Y DE LA SALUD medicine.drug_class animal experiment Amphetamine-Related Disorders Hyperkinesis Motor Activity Article PSYCHOSTIMULANT purl.org/becyt/ford/3.3 [https] Dopamine Dopamine receptor D2 Genetics medicine Animalia Animals NULL MUTANT controlled study dopamine 1 receptor mouse nonhuman Salud Ocupacional Receptors Dopamine D2 dopamine 2 receptor Receptors Dopamine D1 Benzazepines DOPAMINE RECEPTORS Stimulant Mice Inbred C57BL KNOCKOUT chemistry NEUROADAPTATION Dopamine Antagonists Central Nervous System Stimulants |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET Genes Brain Behav. 2008;7(5):568-577 Biblioteca Digital (UBA-FCEN) Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales instacron:UBA-FCEN |
| DOI: | 10.1111/j.1601-183X.2008.00392.x |
| Popis: | Behavioral sensitization to psychostimulants manifests as an increased locomotor response with repeated administration. Dopamine systems are accepted to play a fundamental role in sensitization, but the role of specific dopamine receptor subtypes has not been completely defined. This study used the combination of dopamine D2 receptor-deficient mice and a D1-like antagonist to examine dopamine D1 and D2 receptor involvement in acute and sensitized locomotor responses to methamphetamine. Absence of the dopamine D2 receptor resulted in attenuation of the acute stimulant effects of methamphetamine. Mutant and wild-type mice exhibited sensitization that lasted longer within the time period of the challenge test in the mutant animals. Pretreatment with the D1-like receptor antagonist SCH 23390 produced more potent reductions in the acute and sensitized locomotor responses to methamphetamine in D2 receptor-deficient mice than in wild-type mice; however, the expression of locomotor sensitization when challenged with methamphetamine alone was equivalently attenuated by previous treatment with SCH 23390. These data suggest that dopamine D2 receptors play a key role in the acute stimulant and sensitizing effects of methamphetamine and act in concert with D1-like receptors to influence the acquisition of methamphetamine-induced behavioral sensitization, traits that may influence continued methamphetamine use. Fil: Kelly, M. A.. Oregon Health And Science University; Estados Unidos Fil: Low, M. J.. Oregon Health And Science University; Estados Unidos Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina Fil: Phillips, T. J.. Oregon Health And Science University; Estados Unidos |
| Databáze: | OpenAIRE |
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