Immune reactions in patients with type I and with type II diabetes mellitus
| Autor: | Mária Varsányi, Mária Horváth, I. Balázsi, Zsuzsa Rózsás, Nóra Jovanovich |
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| Rok vydání: | 1987 |
| Předmět: |
Adult
Cytotoxicity Immunologic Male medicine.medical_specialty Cellular immunity Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment T-Lymphocytes Pathogenesis Leukocyte Count Endocrinology Immune system Internal medicine Diabetes mellitus Internal Medicine medicine Leukocytes Cytotoxic T cell Humans Child business.industry Insulin Antibody titer Cell Migration Inhibition General Medicine HLA-DR Antigens medicine.disease Diabetes Mellitus Type 1 Diabetes Mellitus Type 2 Immunology Female business |
| Zdroj: | Experimental and clinical endocrinology. 89(3) |
| ISSN: | 0232-7384 |
| Popis: | Since several data refer to the role of immune processes in the pathogenesis of diabetes mellitus, this study was performed to compare aspecific and specific immune reactions in type I- and in type II diabetic patients over a six month period. The percentage and the absolute number of SRBC-rosette forming active E(A), of theophylline-resistant E(Thr) and of ORCB-rosette forming T(M)-cell subsets proved to be elevated in newly diagnosed type I but reduced in type II diabetic patients. Also an elevated percentage of HLA-DR positive, activated T cells was found in the majority of recent-onset type I diabetics. In the presence of human pancreas extract, a significant inhibition of leucocyte migration, a pronounced and specific cytotoxic capacity of all lymphocyte subsets (especially of the T(G)-cells), and elevated antibody titers (passive haemagglutination, indirect immunofluorescence) were observed in almost all type I diabetics, but only in a few cases of type II patients. After six months, the frequency both of the aspecific and of the specific immune parameters was decreased in type I diabetics, but no changes were observed in the type II diabetics with a previously positive test. The latter patients required insulin therapy at the time of the second investigation. The leucocyte migration inhibition test and the lymphocyte-mediated cytotoxicity are suitable for studying in-vitro-sensitization against pancreatic tissue and they might predict later insulin-dependency in type II diabetic patients. |
| Databáze: | OpenAIRE |
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