Natural compounds with Wnt signal modulating activity
| Autor: | Midori A. Arai, Masami Ishibashi, Rolly G. Fuentes |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Biological Products
Molecular Structure Organic Chemistry Wnt signaling pathway LRP6 Wnt signalling Neurodegenerative Diseases Biology biology.organism_classification Biochemistry Signal Cell biology Wnt Proteins Mechanism of action Neoplasms Drug Discovery medicine Animals Humans medicine.symptom Signal transduction Zebrafish Wnt Signaling Pathway Signal Transduction |
| Zdroj: | Natural product reports. 32(12) |
| ISSN: | 1460-4752 |
| Popis: | Covering: up to 2015 The Wnt signalling pathway is essential in many biological processes. The Wnt signal is associated with several diseases, particularly cancer and neurodegenerative diseases. Recently, high-throughput screening systems have been developed to rapidly identify compounds, including natural compounds, that target the Wnt signal. Some studies on natural modulators of the Wnt signal have also suggested their possible target. This review highlights some important natural compounds reported to regulate Wnt activity and describes their possible mechanism of action. |
| Databáze: | OpenAIRE |
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