Effect of Cyclopentolate on In Vivo Schlemm Canal Microarchitecture in Healthy Subjects
| Autor: | Michael S. Rosman, Robert Ritch, Tarela F. Sarimiye, Jason L. Chien, Mark P. Ghassibi, Sung Chul Park, Jeffrey M. Liebmann, Alon Skaat |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Mydriatics Intraocular pressure medicine.medical_specialty Future studies Glaucoma Limbus Corneae Tonometry Ocular 03 medical and health sciences 0302 clinical medicine In vivo Ophthalmology medicine Humans Prospective Studies Intraocular Pressure business.industry Healthy subjects Mean age Cyclopentolate medicine.disease Healthy Volunteers 030221 ophthalmology & optometry Female sense organs Enhanced depth imaging business Tomography Optical Coherence 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Glaucoma. 26:133-137 |
| ISSN: | 1057-0829 |
| DOI: | 10.1097/ijg.0000000000000599 |
| Popis: | PURPOSE To characterize the in vivo effect of cyclopentolate on the microstructure of Schlemm canal (SC) in healthy eyes. METHODS For healthy subjects, 81 serial horizontal enhanced depth imaging optical coherence tomography B-scans (interval between scans, ∼35 μm) of the nasal corneoscleral limbal area were obtained before and 1 hour after cyclopentolate 1% administration in 1 eye. The structures of aqueous and blood vessels in each scan were used as landmarks to select 50 overlapping scans between the 2 sets of 81 serial scans (before and after cyclopentolate administration). The SC cross-sectional area was measured in each of the 50 selected scans. After 3-dimensional reconstruction, SC volume was determined. RESULTS Twelve eyes (12 healthy subjects) were imaged successfully before and after cyclopentolate administration. Mean age was 27.8±4.9 years (range, 25 to 38 y). Following cyclopentolate administration, mean intraocular pressure did not change significantly (13.9±1.5 to 14.2±1.5 mm Hg; P=0.19). Mean SC cross-sectional area decreased by 17%, from 3563±706 to 2959±460 μm (P |
| Databáze: | OpenAIRE |
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