Expression of Cox-2 and Bcl-2 in Paget's disease of the breast
| Autor: | Mustafa Yildirim, Vildan Kaya, Cumhur Selcuk Topal, Sebnem Ayva, Fatma Nilgun Kapucuoglu, Sevinc Keser, Arsenal Sezgin Alikanoglu, Dinç Süren, Ayse Nimet Karadayi, Seyda Gunduz, Birsel Tutuş |
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| Rok vydání: | 2015 |
| Předmět: |
musculoskeletal diseases
Oncology Adult Cancer Research medicine.medical_specialty Pathology Epidemiology Paget's Disease Mammary Breast Neoplasms Disease Adenocarcinoma Pathogenesis Lesion Immunoenzyme Techniques Young Adult Breast cancer Internal medicine medicine Biomarkers Tumor Humans Aged Neoplasm Staging Retrospective Studies Paget's disease of the breast Aged 80 and over business.industry Carcinoma Ductal Breast Public Health Environmental and Occupational Health Cancer Ductal carcinoma Middle Aged medicine.disease Prognosis Carcinoma Intraductal Noninfiltrating Proto-Oncogene Proteins c-bcl-2 Cyclooxygenase 2 Female medicine.symptom business Follow-Up Studies |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 16(3) |
| ISSN: | 2476-762X |
| Popis: | Background: Paget’s disease (PD) is a rare form of intraepithelial adenocarcinoma that involves breast and extramammarian tissues. It is often associated with ductal carcinoma in situ and/or invasive ductal cancer. Molecular pathways that play a role in development of Paget’s disease are stil unclear. Expression patterns of Cox-2 and bcl-2 were therefore assessed. Materials and Methods: Patients with a histopathological diagnosis of Paget’s disease were included in this study. Patient files were analysed retrospectively. Results: Invasive cancer was diagnosed in 35 (76.1%) of the patients, 7 (15.2%) had ductal carcinoma in situ and 4 (8.7%) patients had no associated neoplasm. Twenty four (52.2%) patients showed COX-2 expression in Paget cells whereas no expression was seen in 22 (47.8%) patients. No relation was found between COX-2 expression and the lesion underlying Paget’s disease (p=0.518). Bcl-2 expression in Paget cells was found positive in 12 (26.1%) and negative in 27 (58,7%) cases. There was no relation between Bcl-2 expression and the lesion accompanying Paget’s disease (p=0.412). No relation was observed between COX-2 expression and Bcl-2 expression (p=0.389). Conclusions: In breast cancer, COX-2 expression is associated with poor prognostic factors. As COX-2 expression increases the tendency to metastasize also increases. In our study we found a significantly high COX-2 expression in Paget’s disease of the breast. We suggest that COX-2 expression and inflammatory processes may play a role in pathogenesis of the Paget’s disease of the breast. |
| Databáze: | OpenAIRE |
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