A breach in the scaffold: The possible role of cytoskeleton dysfunction in the pathogenesis of major depression
| Autor: | Andrew Chi Kin Law, Ginger Tsz Hin Wong, Raymond Chuen-Chung Chang |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Aging
Dendritic spine Dendritic Spines Biology Microtubules Biochemistry Pathogenesis Actin remodeling of neurons Microtubule Animals Humans Cytoskeleton Molecular Biology Depression (differential diagnoses) Actin Depressive Disorder Major Mental Disorders Dendrites Cell biology Actin Cytoskeleton Tubulin Neurology biology.protein Protein Processing Post-Translational Neuroscience Biotechnology |
| Zdroj: | Ageing Research Reviews. 12:67-75 |
| ISSN: | 1568-1637 |
| DOI: | 10.1016/j.arr.2012.08.004 |
| Popis: | Depression is one of the most common psychiatric disorders with inadequately understood disease mechanisms. It has long been considered that dendritic regression and decrease in the number of dendritic spines are involved in depression. Dendrites made up of microtubules and actin filaments form synapses with neighboring neurons, which come together as an important communication network. Cytoskeletal proteins undergo post-translational modifications to define their structure and function. In depression and other psychiatric disorders, post-translational modifications may be disrupted that can result in altered cytoskeletal functions. The disruption of microtubule and actin in terms of morphology and functions may be a leading cause of dendritic regression and decrease in dendritic spine in depression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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