Reliable Functionalization of 5,6-Fused Bicyclic N-Heterocycles Pyrazolopyrimidines and Imidazopyridazines via Zinc and Magnesium Organometallics

Autor:	Saroj Kumar Rout, Agonist Kastrati, Harish Jangra, Kuno Schwärzer, Alisa S. Sunagatullina, Maximilien Garny, Fabio Lima, Cara E. Brocklehurst, Konstantin Karaghiosoff, Hendrik Zipse, Paul Knochel
Rok vydání:	2022
Předmět:	Zinc Pyrimidines Organic Chemistry Indicators and Reagents Magnesium General Chemistry Catalysis
Zdroj:	Chemistry (Weinheim an der Bergstrasse, Germany). 28(33)
ISSN:	1521-3765
Popis:	DFT-calculations allow prediction of the reactivity of uncommon N-heterocyclic scaffolds of pyrazolo[1,5-a]pyrimidines and imidazo[1,2-b]pyridazines and considerably facilitate their functionalization. The derivatization of these N-heterocycles was realized using Grignard reagents for nucleophilic additions to 5-chloropyrazolo[1,5-a]pyrimidines and TMP
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17502ebaf2a5a9c99e54f24bde664baa https://pubmed.ncbi.nlm.nih.gov/35384103 Zobrazit plný text záznamu Plný text