Are all melanomas the same? Spitzoid melanoma is a distinct subtype of melanoma
| Autor: | Julide Tok Celebi, Alan J. Halperin, William S. Twaddell, Klaus J. Busam, Melissa Gill, Eyal Levit, Jason A. Cohen, M D O Joan Mones, David N. Silvers, Gustavo Palacios, David A. Lee |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Proto-Oncogene Proteins B-raf Cancer Research Pathology medicine.medical_specialty Skin Neoplasms Adolescent DNA Mutational Analysis medicine.disease_cause Metastasis Medicine Nevus Humans Child neoplasms Melanoma Aged Mutation Oncogene business.industry Cancer medicine.disease Genes ras Oncology Child Preschool Cancer research Female Mitogen-Activated Protein Kinases business Carcinogenesis V600E Signal Transduction |
| Zdroj: | Cancer. 106(4) |
| ISSN: | 0008-543X |
| Popis: | BACKGROUND Although the majority of melanomas demonstrate high rates of mutations in B-RAF or N-RAS that result in constitutive activation of the mitogen-activated protein kinase-signaling pathway, emerging data suggest molecular differences among melanoma subtypes. In this study, the authors evaluated the contribution of B-RAF and N-RAS mutations to the pathogenesis of Spitzoid melanomas. METHODS In total, 33 Spitzoid melanomas were analyzed for clinical and pathologic characteristics as well as for hot-spot mutations in the B-RAF and N-RAS genes. In the majority of patients (28 of 33 melanomas), the tumors were confined to the skin with no evidence of metastasis (average follow-up, 32.5 mos). There were five metastasizing melanomas (5 of 33 tumors) with regional or systemic spread. RESULTS Of 33 Spitzoid melanomas, only 1 showed the V600E mutation in the B-RAF gene (1 of 33 tumors; 3%). It was noteworthy that none of the metastatic Spitzoid melanomas (0 of 5 tumors; 0%), of which 2 resulted in fatal outcomes, demonstrated mutations in B-RAF or N-RAS. CONCLUSIONS In contrast to the majority of cutaneous melanomas, activating hot-spot mutations in B-RAF or N-RAS were not involved in the pathogenesis of Spitzoid melanoma. These data suggested that Spitzoid melanoma is a distinct form of melanoma with unknown genes and/or signaling pathways involved in its development. Cancer 2006. © 2006 American Cancer Society. |
| Databáze: | OpenAIRE |
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